Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

The ideas that proteins might possess specific functions without being uniquely folded into
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …

Language models have recently emerged as a powerful machine-learning approach for
distilling information from massive protein sequence databases. From readily available …

The mixed lineage kinase domain-like protein (MLKL) has recently been identified as a key
RIP3 (receptor interacting protein 3) downstream component of tumour necrosis factor (TNF) …

The evolutionarily conserved SNARE proteins and their complexes are involved in the
fusion of vesicles with their target membranes; however, the overall organization and …

Although changes in mitochondrial size and arrangement accompany both cellular
differentiation and human disease, the mechanisms that mediate mitochondrial fusion …

Macroautophagy is the major intracellular degradation system delivering cytoplasmic
components to the lysosome/vacuole. We have shown that, in yeast and mammalian cells …

The α-helical coiled coil is one of the principal subunit oligomerization motifs in proteins. Its
most characteristic feature is a heptad repeat pattern of primarily apolar residues that …

Cilia and flagella are widespread cell organelles that have been highly conserved
throughout evolution and play important roles in motility, sensory perception, and the life …

The coiled coil is a common structural motif, formed by approximately 3±5% of all amino
acids in proteins.[1] Typically, it consists of two to five a-helices wrapped around each other …