Discoveries in fruit flies have greatly contributed to our understanding of neuroscience. The
use of an unparalleled wealth of tools, many of which originated between 1910–1960, has …

The fruit fly Drosophila melanogaster has emerged as a key model organism in
neuroscience, in large part due to the concentration of collaboratively generated molecular …

The development of two-component expression systems in Drosophila melanogaster, one of
the most powerful genetic models, has allowed the precise manipulation of gene function in …

As malignant tumours develop, they interact intimately with their microenvironment and can
activate autophagy, a catabolic process which provides nutrients during starvation. How …

Axonal and synaptic degeneration is a hallmark of peripheral neuropathy, brain injury, and
neurodegenerative disease. Axonal degeneration has been proposed to be mediated by an …

Somatic stem cells constantly adjust their self-renewal and lineage commitment by
integrating various environmental cues to maintain tissue homeostasis. Although numerous …

Fruit flies of the genus Drosophila have been an attractive and effective genetic model
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …

Gut homeostasis is controlled by both immune and developmental mechanisms, and its
disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the …

The Hippo signaling pathway is widely considered a master regulator of organ growth
because of the prominent overgrowth phenotypes caused by experimental manipulation of …

Increased glucose metabolism and reprogramming toward aerobic glycolysis are a hallmark
of cancer cells, meeting their metabolic needs for sustained cell proliferation. Metabolic …