Advances in hiPSC isolation and reprogramming and hPSC-CM differentiation have
prompted their therapeutic application and utilization for evaluating potential cardiovascular …

Cardiovascular disease (CVD) caused by anti-cancer drug-induced cardiotoxicity is now the
second leading cause of mortality among cancer survivors. It is necessary to establish …

Early embryonic development represents a sensitive time-window during which the foetus
might be vulnerable to the exposure of environmental contaminants, potentially leading to …

Cardiac contractility modulation (CCM) is a medical device therapy whereby non-excitatory
electrical stimulations are delivered to the myocardium during the absolute refractory period …

Introduction: Pulsed electric field (PEF) cardiac ablation has been recently proposed as a
technique to treat drug resistant atrial fibrillation by inducing cell death through irreversible …

Objective Antineoplastic agent-induced systolic dysfunction is a major reason for interruption
of anticancer treatment. Although targeted anticancer agents infrequently cause systolic …

Two of the most prominent organ systems, the nervous and the cardiovascular systems, are
intricately connected to maintain homeostasis in mammals. Recent years have shown …

The reliable identification of chronic cardiotoxic effects in in vitro screenings is fundamental
for filtering out toxic molecular entities before in vivo animal experimentation and clinical …

Voltage imaging of cardiac electrophysiology with voltage-sensitive dyes has long been a
powerful complement to traditional methods like patch-clamp electrophysiology. Chemically …

Abstract The Health and Environmental Sciences Institute (HESI) is a nonprofit organization
dedicated to resolving global health challenges through collaborative scientific efforts across …