Tissue and organ development during embryogenesis relies on the collective and
coordinated action of many cells. Recent studies have revealed that tissue material …

The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment
of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic …

Pathological morphological changes in tumor tissue enable collective cancer cell
unjamming, a cellular motility transition. However, fundamental questions remain: Is …

The migratory dynamics of cells in physiological processes, ranging from wound healing to
cancer metastasis, rely on contact-mediated cell–cell interactions. These interactions play a …

Although rigidity and jamming transitions have been widely studied in physics and material
science, their importance in a number of biological processes, including embryo …

The interactions between cells and their surrounding extracellular matrix (ECM) are dynamic
and play critical roles in cell migration during development, health, and diseases. Recent …

Cancer cells are mechanically sensitive to physical properties of the microenvironment,
which can affect downstream signaling to promote malignancy, in part through the …

Here, we review recent developments in the literature that provide insight into self-
organization at supracellular scales in vertebrate organ morphogenesis. We briefly present …

Tissue surface tension is one of the key parameters that govern tissue rearrangement,
sha**, and segregation within various compartments during organogenesis, wound …

Dormancy is an evolutionarily conserved protective mechanism widely observed in nature. A
pathological example is found during cancer metastasis, where cancer cells disseminate …