Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …

Mitochondria are primarily responsible for providing the contracting cardiac myocyte with a
continuous supply of ATP. However, mitochondria can rapidly change into death-promoting …

Besides their main function for energy production in form of ATP in processes of oxidative
phosphorylation (OxPhos), mitochondria perform many other important cellular functions …

Background—Whether alterations in mitochondrial morphology affect the susceptibility of the
heart to ischemia/reperfusion injury is unknown. We hypothesized that modulating …

Mitochondrial dynamics and mitophagy have been linked to cardiovascular and
neurodegenerative diseases. Here, we demonstrate that the mitochondrial division dynamin …

During the last decades a considerable amount of research has been focused on cancer.
Recently, tumor cell metabolism has been considered as a possible target for cancer …

Mitofusin-2 (Mfn-2) is a dynamin-like protein that is involved in the rearrangement of the
outer mitochondrial membrane. Research using various experimental systems has shown …

In living cells, growth is the result of coupling between substrate catabolism and multiple
metabolic processes that take place during net biomass formation and maintenance …

Mitochondria form a dynamic network within the cell as a result of balanced fusion and
fission. Despite the established role of mitofusins (MFN1 and MFN2) in mitochondrial fusion …

Mitochondrial dynamics is a recent topic of research in the field of cardiac physiology. The
study of mechanisms involved in the morphological changes and in the mobility of …