Aims Congenital heart disease (CHD) is the most common genetic birth defect, which has
considerable morbidity and mortality. We focused on deciphering key regulators that govern …

In mouse development, long-term silencing by CpG island DNA methylation is specifically
targeted to germline genes; however, the molecular mechanisms of this specificity remain …

Background and Purpose Isoxazole 9 (ISX9) is a neurogenesis‐promoting small molecule
compound that can up‐regulate the expression of NeuroD1 and induce differentiation of …

E‐cadherin (CDH1) is involved in maintaining cell–cell adhesions in embryonic stem cells
(ESCs). However, its function in the context of cell fate decisions is largely unknown. Using …

Prenatal alcohol exposure can cause developmental abnormalities (fetal alcohol spectrum
disorders; FASD), including small eyes, face and brain, and neurobehavioral deficits. These …

Genome-wide map** of transcription factors (TFs) is critical to understand their functions.
In chromatin immunoprecipitation (ChIP)-seq assay, it's challenging to study recruitment of …

Сучасна гормональна замісна терапія ендокринних порушень не може відтворити
складну взаємодію гормонів. Трансплантація клітин є більш фізіологічним підходом до …

Objective: This study focuses on the regulatory role of mRNA export in embryonic stem cell
(ESC) potency and differentiation, vital processes for developmental biology. It investigates …

Cardiovascular disease (CVD) remains the number one cause of death in the United States
and the World. The clinical outcomes of patients with heart failure, a form of CVD, remain …

The Wnt/β-catenin pathway is involved in development, cancer, and embryonic stem cell
(ESC) maintenance; its dual role in stem cell self-renewal and differentiation is still …