Recent advances (2015–2016) in anticancer hybrids
In spite of the development of a large number of novel anticancer drugs over the years,
Cancer remains as a prominent cause of death, worldwide. Numerous drugs that are …
Cancer remains as a prominent cause of death, worldwide. Numerous drugs that are …
Spirooxindole: a versatile biologically active heterocyclic scaffold
Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural
spirooxindole-containing compounds have been identified as bio-promising agents …
spirooxindole-containing compounds have been identified as bio-promising agents …
Structural insights of oxindole based kinase inhibitors as anticancer agents: Recent advances
Small-molecule kinase inhibitors are being continuously explored as new anticancer
therapeutics. Kinases are the phosphorylating enzymes which regulate numerous cellular …
therapeutics. Kinases are the phosphorylating enzymes which regulate numerous cellular …
Tetrazole hybrids with potential anticancer activity
J Zhang, S Wang, Y Ba, Z Xu - European journal of medicinal chemistry, 2019 - Elsevier
Cancer is one of the main causes of death throughout the world. The anticancer agents are
indispensable for the treatment of various cancers, but most of them currently on the market …
indispensable for the treatment of various cancers, but most of them currently on the market …
Recent advances in isatin hybrids as potential anticancer agents
Z Ding, M Zhou, C Zeng - Archiv der Pharmazie, 2020 - Wiley Online Library
The isatin framework is a useful template for the development of novel anticancer agents.
This is exemplified by the fact that several isatin‐based anticancer agents, such as …
This is exemplified by the fact that several isatin‐based anticancer agents, such as …
Exploration of carbamide derived pyrimidine-thioindole conjugates as potential VEGFR-2 inhibitors with anti-angiogenesis effect
The development of new small molecules from known structural motifs through molecular
hybridization is one of the trends in drug discovery. In this connection, we have combined …
hybridization is one of the trends in drug discovery. In this connection, we have combined …
Regioselective ring-opening of spiro-epoxyoxindoles by a dual-ligand zinc-based metal–organic framework as an efficient heterogeneous catalyst
Develo** a heterogeneous catalyst for alcoholysis/hydrolysis of spiro-epoxyoxindoles to
form β-alkoxy/β-hydroxy alcohols is an emerging and promising research area in the …
form β-alkoxy/β-hydroxy alcohols is an emerging and promising research area in the …
Isatin–azole hybrids and their anticancer activities
Y Hou, C Shang, H Wang, J Yun - Archiv der Pharmazie, 2020 - Wiley Online Library
Isatin and azole moieties, which have the ability to form various noncovalent interactions
with different therapeutic targets, are common pharmacophores in drug development. Isatin …
with different therapeutic targets, are common pharmacophores in drug development. Isatin …
Biocatalytic enantioselective synthesis of chiral β-hydroxy nitriles using cyanohydrins as cyano sources
XE Guan, RP Miao, X Hua, X **, GZ Deng, BD Cui… - ACS …, 2023 - ACS Publications
The development of catalytic enantioselective cyanation methods for preparing valuable
chiral nitriles is of great interest in the areas of pharmaceutical synthesis and organic …
chiral nitriles is of great interest in the areas of pharmaceutical synthesis and organic …
Conventional and microwave-assisted synthesis of new 1H-benzimidazole-thiazolidinedione derivatives: A potential anticancer scaffold
A series of new benzimidazole bearing thiazolidinedione derivatives has been designed,
synthesized by using conventional as well as microwave-assisted methods. Microwave …
synthesized by using conventional as well as microwave-assisted methods. Microwave …