Kidney disease is a major driver of mortality among patients with diabetes and diabetic
kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases …

Recent studies have provided further evidence for the presence of many components of the
RAS in glomerular structures, which supports the importance of locally produced …

We investigated whether hypertension induced by maternal lipopolysaccharide (LPS)
administration during gestation is linked to peripheral vascular and renal hemodynamic …

Chronic kidney disease (CKD) occurs in more than 50% of patients with obstructive sleep
apnea (OSA). However, the impact of intermittent hypoxia (IH) on renal function and oxygen …

The degradation of ANG II by angiotensin-converting enzyme 2 (ACE2), leading to the
formation of ANG (1–7), is an important step in the regulation of the renin-angiotensin …

Diabetes mellitus with its attendant complications is a significant cause of morbidity and
mortality with diabetic nephropathy being the leading cause of end stage renal disease in …

The role of the intrarenal renin-angiotensin system (iRAS) in diabetic kidney disease (DKD)
progression remains unclear. In this study, we generated mice with renal tubule-specific …

Diabetic nephropathy (DN) is a long-term complication of diabetes mellitus. The
characteristic of early-stage DN is glomerular hyperfiltration that has been linked to renal …

Diabetic nephropathy (DN) and hypertension are prime causes for end-stage renal disease
(ESRD) that often coexist in patients, but are seldom studied in combination. Kidney …

In early diabetic nephropathy (DN), recent studies have shown that albuminuria stems
mostly from alterations in tubular function rather than from glomerular damage. Several …