Amyloid β protein (AβP) is the major constituent of senile plaques associated with
Alzheimer's disease (AD). However, its mechanistic role in AD pathogenesis is poorly …

Neurodegenerative diseases as diverse as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob
disease share a common pathogenetic mechanism involving aggregation and deposition of …

Extensive research causally links amyloid-β peptide (Aβ) to Alzheimer's disease, although
the pathologically relevant Aβ conformation remains unclear. Aβ spontaneously aggregates …

This chapter outlines protocols that produce homogenous preparations of oligomeric and
fibrillar amyloid-β peptide (Aβ). While there are several isoforms of this peptide, the 42 …

β-Amyloid (Aβ) acquires toxicity by self-aggregation. To identify and characterize the toxic
form (s) of Aβ aggregates, we examined in vitro aggregation conditions by using large …

Alzheimer's disease (AD) is characterized by the deposition of β-sheet–rich, insoluble
amyloid β-peptide (Aβ) plaques; however, plaque burden is not correlated with cognitive …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing
population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of …

The filamentous bacteriophage fd bind a cell target with exquisite specificity through its few
copies of display peptides, whereas nanoparticles functionalized with hundreds to …

Soluble oligomeric aggregates of the amyloid-β peptide (Aβ) have been implicated in the
pathogenesis of Alzheimer's disease (AD). Although the conformation adopted by Aβ within …

Assembly of the amyloid β-protein (Aβ) into neurotoxic oligomers and fibrils is a seminal
event in Alzheimer's disease. Understanding the earliest phases of Aβ assembly, including …