Ion channels are involved in regulating cell proliferation and apoptosis (programed cell
death). Since increased cellular proliferation and inhibition of apoptosis are characteristic …

Head and neck cancers are a highly complex and heterogeneous group of malignancies
that involve very diverse anatomical structures and distinct aetiological factors, treatments …

To survive, cells need to avoid excessive volume change that jeopardizes structural integrity
and stability of the intracellular milieu. Searching for the molecular identity of volume …

It was shown in this study that knockdown of ClC-3 expression by ClC-3 siRNA prevented
the activation of hypotonicity-induced chloride currents and arrested cells at the G0/G1 …

Although extensively studied, the mechanisms by which estrogen promotes breast cancer
growth remain to be fully elucidated. Tamoxifen, an antiestrogen agent to treat ERα+ breast …

Recent evidences show that cationic fluxes play a pivotal role in cell apoptosis. In this study,
the roles of Cl− channels in paclitaxel-induced apoptosis were investigated in …

Estrogen plays important roles in regulation of bone formation. Cl− channels in the ClC
family are expressed in osteoblasts and are associated with bone physiology and pathology …

Chemotherapy is the most common therapeutic strategy used to treat osteosarcoma. The
present study aimed to investigate the effects of functionally activated chloride channels on …

Introduction: Metabolic disorders are an important health concern that threatens life and
burdens society severely. ClC-3 is a member of the chloride voltage-gated channel family …

Background: The marine-derived kinase inhibitor fascaplysin down-regulates the PI3K
pathway in cancer cells. Since this pathway also plays an essential role in platelet signaling …