CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

Proteins of the small ubiquitin-related modifier (SUMO) family are conjugated to proteins to
regulate such cellular processes as nuclear transport, transcription, chromosome …

Small-molecule chemical probes are among the most important tools to study the function of
proteins in cells and organisms. Regrettably, the use of weak and non-selective small …

Malignant transformation and maintenance of the malignant phenotype depends on
oncogenic and non-oncogenic proteins that are essential to mediate oncogene signaling …

Influenza A virus (IAV) infection mobilizes bone marrow-derived macrophages (BMDM) that
gradually undergo transition to tissue-resident alveolar macrophages (TR-AM) in the …

The transition element zinc, which has recently been identified as an intracellular second
messenger, has been implicated in various signaling pathways, including those leading to …

Herein we chronicle the discovery of CX-4945 (25n), a first-in-class, orally bioavailable ATP-
competitive inhibitor of protein kinase CK2 in clinical trials for cancer. CK2 has long been …

CK2 genes are overexpressed in many human cancers, and most often overexpression is
associated with worse prognosis. Site-specific expression in mice leads to cancer …

At variance with most oncogenic protein kinases whose malignancy is generally due to
genetic alterations conferring constitutive activity, CK2 is a highly pleiotropic Ser/Thr protein …