Protein homeostasis or proteostasis is an equilibrium of biosynthetic production, folding and
transport of proteins, and their timely and efficient degradation. Proteostasis is guaranteed …

Excessive oxidative stress triggers cerebrovascular and neurodegenerative diseases
resulting in acute and chronic brain injury. However, the underlying mechanisms remain …

Proteome maintenance in contracting skeletal and cardiac muscles depends on the
chaperone-regulating protein BAG3. Reduced BAG3 activity leads to muscle weakness and …

This study was designed to probe the effect of chaperone-assisted selective autophagy
(CASA) on the maintenance of proteostasis during exhaustive exercise and uncover the …

Abstract The Fourth Cell Stress Society International workshop on small heat shock proteins
(sHSPs), a follow-up to successful workshops held in 2014, 2016 and 2018, took place as a …

Sepsis-associated encephalopathy (SAE) is associated with a higher risk of cognitive
deficits; however, its potential mechanisms are still unknow. Recently, researches show that …

Accumulation of mutant proteins in cells can induce proteinopathies and cause functional
damage to organs. Recently, the Cingulin (CGN) protein has been shown to maintain the …

Small heat shock proteins (sHSPs) are common molecular chaperone proteins that function
in various biological processes, and serve indispensable roles in maintaining cellular …

Variants in HSPB8 are predominantly associated with peripheral neuropathies, but their
occurrence in myopathies remains exceedingly rare. The genetic and clinical spectrum of …

Heat shock protein family B (small) member 8 (HSPB8) is a 22 kDa ubiquitously expressed
protein belonging to the family of small heat shock proteins. HSPB8 is involved in various …