Innate immunity is a primordial system that has a primary role in lung antimicrobial defenses.
Recent advances in understanding the recognition systems by which cells of the innate …

Endotoxin (lipopolysaccharides; LPS) plays a pivotal role in many pathophysiological states
and diseases. Although the major pathways involved in LPS signal transduction are …

Human primary monocytes are heterogeneous in terms of phenotype and function, but are
sub-divided only based on CD16 and CD14 expression. CD16 expression distinguishes a …

BACKGROUND & AIMS: Premature neonates are predisposed to necrotizing enterocolitis
(NEC), an idiopathic, inflammatory bowel necrosis. We investigated whether NEC occurs in …

We evaluated whether a goal-directed protocol, without measurement of central venous
oxygen saturation, would improve survival in medical intensive care unit (ICU) patients with …

AIM: To explore lipocalin-2 (LCN-2) expression and its possible role and mechanism (s) of
production in rat models of diet-inducible fatty liver. METHODS: Fatty liver was triggered in …

Monocytes and macrophages that originate from common myeloid progenitors perform
various crucial roles in the innate immune system. Stimulation with LPS combined with TLR4 …

Rationale: Interactions of nontypeable Haemophilus influenzae (NTHI) with macrophages
are implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD) …

The recognition of bacterial lipopolysaccharide (LPS) is principally mediated by either
membrane-bound or soluble form of the glycoprotein CD14 and CD14-associated signal …

Proteoglycans (PGs) and their associated glycosaminoglycan side chains are effectors of
inflammation, but little is known about changes to the composition of PGs in response to …