Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

M Bäck, A Yurdagul Jr, I Tabas, K Öörni… - Nature Reviews …, 2019 - nature.com
Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …

Efferocytosis in atherosclerosis

SS Adkar, NJ Leeper - Nature Reviews Cardiology, 2024 - nature.com
Cardiovascular disease is the leading cause of death worldwide, and it commonly results
from atherosclerotic plaque progression. One of the increasingly recognized drivers of …

Association analyses based on false discovery rate implicate new loci for coronary artery disease

CP Nelson, A Goel, AS Butterworth, S Kanoni… - Nature …, 2017 - nature.com
Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified
66 loci at'genome-wide significance'(P< 5× 10− 8) at the time of this analysis, but a much …

Mechanisms and consequences of defective efferocytosis in atherosclerosis

A Yurdagul Jr, AC Doran, B Cai, G Fredman… - Frontiers in …, 2018 - frontiersin.org
Efficient clearance of apoptotic cells, termed efferocytosis, critically regulates normal
homeostasis whereas defective uptake of apoptotic cells results in chronic and non …

Consideration of sex differences in design and reporting of experimental arterial pathology studies—statement from ATVB council

P Robinet, DM Milewicz, LA Cassis… - … , and vascular biology, 2018 - ahajournals.org
There are many differences in arterial diseases between men and women, including
prevalence, clinical manifestations, treatments, and prognosis. The new policy of the …

The role of efferocytosis in atherosclerosis

Y Kojima, IL Weissman, NJ Leeper - Circulation, 2017 - ahajournals.org
The necrotic core has long been a hallmark of the vulnerable atherosclerotic plaque.
Although apoptotic cells are cleared quickly in almost all other tissue beds, their removal …

Selection of metastasis competent subclones in the tumour interior

Y Zhao, X Fu, JI Lopez, A Rowan, L Au… - Nature ecology & …, 2021 - nature.com
The genetic evolutionary features of solid tumour growth are becoming increasingly well
described, but the spatial and physical nature of subclonal growth remains unclear. Here …

Clonally expanding smooth muscle cells promote atherosclerosis by esca** efferocytosis and activating the complement cascade

Y Wang, V Nanda, D Direnzo, J Ye, S **ao… - Proceedings of the …, 2020 - pnas.org
Atherosclerosis is the process underlying heart attack and stroke. Despite decades of
research, its pathogenesis remains unclear. Dogma suggests that atherosclerotic plaques …

Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms

A Tajbakhsh, M Rezaee, PT Kovanen… - Pharmacology & …, 2018 - Elsevier
Atherosclerosis is a dynamic and progressive inflammatory process in the intimal layer of
large and medium-sized arteries, and it is the major contributor to the atherosclerotic …

The role of ANRIL in atherosclerosis

I Razeghian-Jahromi, A Karimi Akhormeh… - Disease …, 2022 - Wiley Online Library
There is a huge number of noncoding RNA (ncRNA) transcripts in the cell with important
roles in modulation of different mechanisms. ANRIL is a long ncRNA with 3.8 kb length that …