[HTML][HTML] Structural features of subtype-selective EP receptor modulators
T Markovič, Ž Jakopin, MS Dolenc… - Drug discovery today, 2017 - Elsevier
Highlights•PGE2 receptor subtypes EP1–4 are valuable drug targets.•Structural features for
subtype-selective activity of EP1–4 receptor modulators are presented.•Binding affinities …
subtype-selective activity of EP1–4 receptor modulators are presented.•Binding affinities …
Enzymes and Receptors of Prostaglandin Pathways with Arachidonic Acid-derived Versus Eicosapentaenoic Acid-derived Substrates and Products*♦
M Wada, CJ DeLong, YH Hong, CJ Rieke… - Journal of Biological …, 2007 - ASBMB
Dietary fish oil containing ω3 highly unsaturated fatty acids has cardioprotective and anti-
inflammatory effects. Prostaglandins (PGs) and thromboxanes are produced in vivo both …
inflammatory effects. Prostaglandins (PGs) and thromboxanes are produced in vivo both …
[HTML][HTML] Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 …
BJ Whittle, AM Silverstein, DM Mottola… - Biochemical …, 2012 - Elsevier
The prostacyclin analogues, iloprost and treprostinil are extensively used in treating
pulmonary hypertension. Their binding profile and corresponding biochemical cellular …
pulmonary hypertension. Their binding profile and corresponding biochemical cellular …
Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype
C Qu, C Mao, P **: a general strategy for efficient stereoretentive catalytic olefin metathesis. The concept, methodological implications, and applications to …
C Xu, X Shen, AH Hoveyda - Journal of the American Chemical …, 2017 - ACS Publications
In situ methylene cap** is introduced as a practical and broadly applicable strategy that
can expand the scope of catalyst-controlled stereoselective olefin metathesis considerably …
can expand the scope of catalyst-controlled stereoselective olefin metathesis considerably …
Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in …
NA Sharif, CR Kelly, JY Crider… - Journal of Ocular …, 2003 - liebertpub.com
Natural prostaglandins (PGs) such as PGD2, PGE2, PGF22 α, and PGI2 exhibited the
highest affinity for their respective cognate receptors, but were the least selective agents …
highest affinity for their respective cognate receptors, but were the least selective agents …
Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor
Misoprostol is a life-saving drug in many develo** countries for women at risk of post-
partum hemorrhaging owing to its affordability, stability, ease of administration and clinical …
partum hemorrhaging owing to its affordability, stability, ease of administration and clinical …
Role of COX‐2‐derived PGE2 on vascular stiffness and function in hypertension
MS Avendaño, S Martinez‐Revelles… - British journal of …, 2016 - Wiley Online Library
Background and Purpose Prostanoids derived from COX‐2 and EP receptors are involved in
vascular remodelling in different cardiovascular pathologies. This study evaluates the …
vascular remodelling in different cardiovascular pathologies. This study evaluates the …