Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

While the description of resistance to quinolones is almost as old as these antimicrobial
agents themselves, transferable mechanisms of quinolone resistance (TMQR) remained …

The development of new antibacterial drugs with different mechanisms of action is urgently
needed to address antimicrobial resistance. MraY is an essential membrane enzyme …

Antimicrobial resistance has become a significant threat to global public health, thus
precipitating an exigent need for new drugs with improved therapeutic efficacy. In this …

Novel antibacterial agents are needed to address the emergence of global antibiotic
resistance. MraY is a promising candidate for antibiotic development because it is the target …

Four tunicamycin class compounds, tunicamycin VII (1), tunicamycin VIII (2), corynetoxin
U17a (3), and tunicamycin IX (4), were isolated from the culture broth of the marine-derived …

This article reviews the structures and biological activities of several classes of uridine-
containing nucleoside antibiotics (tunicamycins, mureidomycins/pacidamycins …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains the
leading cause of death from an infectious bacterium and is responsible for 1.8 million deaths …

The widespread emergence of antibiotic resistance in pathogens necessitates the
development of antibacterial agents inhibiting underexplored targets in bacterial …