Ventral tegmental area: cellular heterogeneity, connectivity and behaviour
M Morales, EB Margolis - Nature Reviews Neuroscience, 2017 - nature.com
Dopamine-releasing neurons of the ventral tegmental area (VTA) have central roles in
reward-related and goal-directed behaviours. VTA dopamine-releasing neurons are …
reward-related and goal-directed behaviours. VTA dopamine-releasing neurons are …
The transition to compulsion in addiction
Compulsion is a cardinal symptom of drug addiction (severe substance use disorder).
However, compulsion is observed in only a small proportion of individuals who repeatedly …
However, compulsion is observed in only a small proportion of individuals who repeatedly …
The spatial and cell-type distribution of SARS-CoV-2 receptor ACE2 in the human and mouse brains
By engaging angiotensin-converting enzyme 2 (ACE2 or Ace2), the novel pathogenic
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades host cells and …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades host cells and …
Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons
The lateral hypothalamic area (LHA) coordinates an array of fundamental behaviors,
including slee**, waking, feeding, stress and motivated behavior. The wide spectrum of …
including slee**, waking, feeding, stress and motivated behavior. The wide spectrum of …
Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
K Timper, JC Brüning - Disease models & mechanisms, 2017 - journals.biologists.com
The 'obesity epidemic'represents a major global socioeconomic burden that urgently calls
for a better understanding of the underlying causes of increased weight gain and its …
for a better understanding of the underlying causes of increased weight gain and its …
Overlap** brain circuits for homeostatic and hedonic feeding
Central regulation of food intake is a key mechanism contributing to energy homeostasis.
Many neural circuits that are thought to orchestrate feeding behavior overlap with the brain's …
Many neural circuits that are thought to orchestrate feeding behavior overlap with the brain's …
Evolving concepts of emotion and motivation
KC Berridge - Frontiers in psychology, 2018 - frontiersin.org
This review takes a historical perspective on concepts in the psychology of motivation and
emotion, and surveys recent developments, debates and applications. Old debates over …
emotion, and surveys recent developments, debates and applications. Old debates over …
[HTML][HTML] Inhibitory input from the lateral hypothalamus to the ventral tegmental area disinhibits dopamine neurons and promotes behavioral activation
Projections from the lateral hypothalamus (LH) to the ventral tegmental area (VTA),
containing both GABAergic and glutamatergic components, encode conditioned responses …
containing both GABAergic and glutamatergic components, encode conditioned responses …
The physiological control of eating: signals, neurons, and networks
AG Watts, SE Kanoski, G Sanchez-Watts… - Physiological …, 2022 - journals.physiology.org
During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …
Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice
K Zhou, H Xu, S Lu, S Jiang, G Hou, X Deng… - Nature …, 2022 - nature.com
The nucleus accumbens (NAc) is critical in mediating reward seeking and is also involved in
negative emotion processing, but the cellular and circuitry mechanisms underlying such …
negative emotion processing, but the cellular and circuitry mechanisms underlying such …