Whole‐body endothermy: ancient, homologous and widespread among the ancestors of mammals, birds and crocodylians
The whole‐body (tachymetabolic) endothermy seen in modern birds and mammals is long
held to have evolved independently in each group, a reasonable assumption when it was …
held to have evolved independently in each group, a reasonable assumption when it was …
[PDF][PDF] Skeletal muscle thermogenesis and its role in whole body energy metabolism
M Periasamy, JL Herrera… - Diabetes & metabolism …, 2017 - synapse.koreamed.org
Obesity and diabetes has become a major epidemic across the globe. Controlling obesity
has been a challenge since this would require either increased physical activity or reduced …
has been a challenge since this would require either increased physical activity or reduced …
The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice
Obesity is a chronic disease that contributes to the development of insulin resistance, type 2
diabetes (T2D), and cardiovascular risk. Glucose-dependent insulinotropic polypeptide …
diabetes (T2D), and cardiovascular risk. Glucose-dependent insulinotropic polypeptide …
Uncoupling of sarcoendoplasmic reticulum calcium ATPase pump activity by sarcolipin as the basis for muscle non-shivering thermogenesis
NC Bal, M Periasamy - Philosophical Transactions of the …, 2020 - royalsocietypublishing.org
Thermogenesis in endotherms relies on both shivering and non-shivering thermogenesis
(NST). The role of brown adipose tissue (BAT) in NST is well recognized, but the role of …
(NST). The role of brown adipose tissue (BAT) in NST is well recognized, but the role of …
Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice
Thermogenesis is an important homeostatic mechanism essential for survival and normal
physiological functions in mammals. Both brown adipose tissue (BAT)(ie uncoupling protein …
physiological functions in mammals. Both brown adipose tissue (BAT)(ie uncoupling protein …
Sarcolipin signaling promotes mitochondrial biogenesis and oxidative metabolism in skeletal muscle
The major objective of this study was to understand the molecular basis of how sarcolipin
uncoupling of SERCA regulates muscle oxidative metabolism. Using genetically engineered …
uncoupling of SERCA regulates muscle oxidative metabolism. Using genetically engineered …
Sarcolipin: a key thermogenic and metabolic regulator in skeletal muscle
M Pant, NC Bal, M Periasamy - Trends in Endocrinology & Metabolism, 2016 - cell.com
Skeletal muscle constitutes∼ 40% of body mass and has the capacity to play a major role as
thermogenic, metabolic, and endocrine organ. In addition to shivering, muscle also …
thermogenic, metabolic, and endocrine organ. In addition to shivering, muscle also …
Role of SERCA and sarcolipin in adaptive muscle remodeling
PJ Chambers, ES Juracic… - American Journal of …, 2022 - journals.physiology.org
Sarcolipin (SLN) is a small regulatory protein that inhibits the sarco (endo) plasmic reticulum
Ca2+-ATPase (SERCA) pump. When bound to SERCA, SLN reduces the apparent Ca2+ …
Ca2+-ATPase (SERCA) pump. When bound to SERCA, SLN reduces the apparent Ca2+ …
Increased reliance on muscle-based thermogenesis upon acute minimization of brown adipose tissue function
Skeletal muscle has been suggested as a site of nonshivering thermogenesis (NST) besides
brown adipose tissue (BAT). Studies in birds, which do not contain BAT, have demonstrated …
brown adipose tissue (BAT). Studies in birds, which do not contain BAT, have demonstrated …
Linking biochemical and structural states of SERCA: achievements, challenges, and new opportunities
Sarcoendoplasmic reticulum calcium ATPase (SERCA), a member of the P-type ATPase
family of ion and lipid pumps, is responsible for the active transport of Ca2+ from the …
family of ion and lipid pumps, is responsible for the active transport of Ca2+ from the …