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Drug-targeting methodologies with applications: A review
C Kleinstreuer, Y Feng… - World Journal of Clinical …, 2014 - pmc.ncbi.nlm.nih.gov
Targeted drug delivery to solid tumors is a very active research area, focusing mainly on
improved drug formulation and associated best delivery methods/devices. Drug-targeting …
improved drug formulation and associated best delivery methods/devices. Drug-targeting …
Lung deposition analyses of inhaled toxic aerosols in conventional and less harmful cigarette smoke: a review
C Kleinstreuer, Y Feng - … journal of environmental research and public …, 2013 - mdpi.com
Inhaled toxic aerosols of conventional cigarette smoke may impact not only the health of
smokers, but also those exposed to second-stream smoke, especially children. Thus, less …
smokers, but also those exposed to second-stream smoke, especially children. Thus, less …
[HTML][HTML] Prediction of airway deformation effect on pulmonary air-particle dynamics: A numerical study
Most existing whole lung models neglect the airway deformation kinematics and assume the
lung airways are static. However, neglecting the airway deformation effect on pulmonary air …
lung airways are static. However, neglecting the airway deformation effect on pulmonary air …
Computational transport, phase change and deposition analysis of inhaled multicomponent droplet–vapor mixtures in an idealized human upper lung model
Y Feng, C Kleinstreuer, N Castro, A Rostami - Journal of aerosol science, 2016 - Elsevier
Numerous inhalable aerosols consist of multiple nano-to-microscale solid or liquid particles
with dissolved or embedded compounds, as well as associated vapors. In general, of …
with dissolved or embedded compounds, as well as associated vapors. In general, of …
Lung aerosol dynamics of airborne influenza A virus-laden droplets and the resultant immune system responses: An in silico study
Abstract Influenza A Virus (IAV) replications start from the deposition of inhaled virus-laden
droplets on the epithelial cells in the pulmonary tracts. In order to understand the local …
droplets on the epithelial cells in the pulmonary tracts. In order to understand the local …
Prediction of the carrier shape effect on particle transport, interaction and deposition in two dry powder inhalers and a mouth-to-G13 human respiratory system: A CFD …
Documentation of comparability between generic inhaler designs and the reference listed
drug (RLD) inhalers is essential for regulatory approval of the products. Such assessments …
drug (RLD) inhalers is essential for regulatory approval of the products. Such assessments …
Impact of electronic cigarette heating coil resistance on the production of reactive carbonyls, reactive oxygen species and induction of cytotoxicity in human lung …
Electronic cigarette (e-cigarette; e-cig) use has grown exponentially in recent years despite
their unknown health effects. E-cig aerosols are now known to contain hazardous chemical …
their unknown health effects. E-cig aerosols are now known to contain hazardous chemical …
[HTML][HTML] Cytotoxic evaluation of e-liquid aerosol using different lung-derived cell models
S Scheffler, H Dieken, O Krischenowski… - International Journal of …, 2015 - mdpi.com
The in vitro toxicological evaluation of e-liquid aerosol is an important aspect of consumer
protection, but the cell model is of great significance. Due to its water solubility, e-liquid …
protection, but the cell model is of great significance. Due to its water solubility, e-liquid …
Cigarette smoke induces epithelial-to-mesenchymal transition, stemness, and metastasis in lung adenocarcinoma cells via upregulated RUNX-2/galectin-3 pathway
Aims An elevated level of galectin-3, a carbohydrate-binding lectin implicated in
tumorigenesis, metastasis, and epithelial-mesenchymal transition (EMT), has been found in …
tumorigenesis, metastasis, and epithelial-mesenchymal transition (EMT), has been found in …
The customizable E-cigarette resistance influences toxicological outcomes: Lung degeneration, inflammation, and oxidative stress-induced in a rat model
Despite the knowledge gap regarding the risk-benefit ratio of the electronic cigarette (e-cig),
its use has grown exponentially, even in teenagers. E-cig vapor contains carcinogenic …
its use has grown exponentially, even in teenagers. E-cig vapor contains carcinogenic …