Filament formation by non-cytoskeletal enzymes has been known for decades, yet only
relatively recently has its wide-spread role in enzyme regulation and biology come to be …

Both, antibiotic persistence and antibiotic resistance characterize phenotypes of survival in
which a bacterial cell becomes insensitive to one (or even) more antibiotic (s). However, the …

Many replication initiators form higher-order oligomers that process host replication origins
to promote replisome formation. In addition to dedicated duplex-DNA-binding domains …

In eukaryotes, DNA replication is coupled to the cell cycle through the actions of cyclin-
dependent kinases and associated factors. In bacteria, the prevailing view, based primarily …

Persistence has evolved as a potent survival strategy to overcome adverse environmental
conditions. This capability is common to almost all bacteria, including all human bacterial …

Replication of the bacterial chromosome initiates at a single origin of replication that is
called oriC. This occurs via the concerted action of numerous proteins, including DnaA …

During the cell division cycle of all bacteria, DNA-protein complexes termed orisomes trigger
the onset of chromosome duplication. Orisome assembly is both staged and stringently …

To ensure proper timing of chromosome duplication during the cell cycle, bacteria must
carefully regulate the activity of initiator protein DnaA and its interactions with the unique …

Control of DNA replication initiation is essential for normal cell growth. A unifying
characteristic of DNA replication initiator proteins across the kingdoms of life is their …

In Escherichia coli, the replication origin oriC consists of two functional regions: the duplex
unwinding element (DUE) and its flanking DnaA-assembly region (DAR). ATP-DnaA …