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Modulation of cellular processes by histone and non-histone protein acetylation
Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …
Genome modeling: from chromatin fibers to genes
The intricacies of the 3D hierarchical organization of the genome have been approached by
many creative modeling studies. The specific model/simulation technique combination …
many creative modeling studies. The specific model/simulation technique combination …
Histone dynamics mediate DNA unwrap** and sliding in nucleosomes
Nucleosomes are elementary building blocks of chromatin in eukaryotes. They tightly
wrap∼ 147 DNA base pairs around an octamer of histone proteins. How nucleosome …
wrap∼ 147 DNA base pairs around an octamer of histone proteins. How nucleosome …
The fork protection complex recruits FACT to reorganize nucleosomes during replication
Chromosome replication depends on efficient removal of nucleosomes by accessory factors
to ensure rapid access to genomic information. Here, we show this process requires …
to ensure rapid access to genomic information. Here, we show this process requires …
Molecular dynamics simulations of nucleosomes are coming of age
Understanding the function of eukaryotic genomes, including the human genome, is
undoubtedly one of the major scientific challenges of the 21st century. The cornerstone of …
undoubtedly one of the major scientific challenges of the 21st century. The cornerstone of …
Machines on genes through the computational microscope
Macromolecular machines acting on genes are at the core of life's fundamental processes,
including DNA replication and repair, gene transcription and regulation, chromatin …
including DNA replication and repair, gene transcription and regulation, chromatin …
Conformational dynamics of the nucleosomal histone H2B tails revealed by molecular dynamics simulations
Epigenetic modifications of histone N-terminal tails play a critical role in regulating the
chromatin structure and biological processes such as transcription and DNA repair. One of …
chromatin structure and biological processes such as transcription and DNA repair. One of …
Histone tail network and modulation in a nucleosome
The structural unit of eukaryotic chromatin is a nucleosome, comprising two histone
H2A/H2B heterodimers and one histone (H3/H4) 2 tetramer, wrapped around by∼ 146-bp …
H2A/H2B heterodimers and one histone (H3/H4) 2 tetramer, wrapped around by∼ 146-bp …
Histone modification in psoriasis: Molecular mechanisms and potential therapeutic targets
R Liu, L Zhang, K Zhang - Experimental Dermatology, 2024 - Wiley Online Library
Psoriasis is an immune‐mediated, inflammatory disease. Genetic and environmental
elements are involved in the nosogenesis of this illness. Epigenetic inheritance serves as …
elements are involved in the nosogenesis of this illness. Epigenetic inheritance serves as …
[HTML][HTML] H2A-H2B histone dimer plasticity and its functional implications
The protein core of the nucleosome is composed of an H3-H4 histone tetramer and two H2A-
H2B histone dimers. The tetramer organizes the central 60 DNA bp, while H2A-H2B dimers …
H2B histone dimers. The tetramer organizes the central 60 DNA bp, while H2A-H2B dimers …