Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Betulinic acid (BA) is a lupane‐type pentacyclic triterpene, distributed ubiquitously
throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities …

Triterpenoids are natural products from plants and many other organisms that have various
biological activities, such as antitumor, antiviral, antimicrobial, and protective activities. This …

Simple Summary Although there are various treatments for tumors, chemotherapy is still one
of the most dominant and irreplaceable treatment modalities nowadays. Unfortunately …

An important method of drug discovery is examination of diverse life forms, including
medicinal plants and natural products or bioactive compounds isolated from these sources …

Introduction: Betulinic acid (BA) is a triterpenoid that can be obtained from renewable
resources. BA is cytotoxic to many human tumor cell lines mainly by apoptosis but cell death …

Betulin and betulinic acid have been widely studied for their anticancer activities. However,
their further development is limited due to low bioavailability, poor aqueous solubility, and …

Betulinic acid (BA) and its natural analogues betulin (BN), betulonic (BoA), and 23-
hydroxybetulinic (HBA) acids are lupane-type pentacyclic triterpenoids. They are present in …

Mitochondria are dynamic organelles managing crucial processes of cellular metabolism
and bioenergetics. Enabling rapid cellular adaptation to altered endogenous and …

The combination of the “correct” triterpenoid, the “correct” spacer and rhodamine B (RhoB)
seems to be decisive for the ability of the conjugate to accumulate in mitochondria. So far …