Monoclonal antibodies (mAbs) are one of the most important classes of therapeutic proteins,
which are used to treat a wide number of diseases (eg, oncology, inflammation and …

Large-molecule antibody biologics have revolutionized medicine owing to their superior
target specificity, pharmacokinetic and pharmacodynamic properties, safety and toxicity …

Antibodies are well established in mainstream clinical practice and present an exciting area
for collaborative research and development in industry and academia alike. In this review …

Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been
the most widely used excipients for the stabilization of protein therapeutics for years. In …

Screening for pharmaceutically viable stability from measurements of thermally induced
protein unfolding and short-term accelerated stress underpins much molecule design …

Spectroscopic analysis using the Terahertz frequencies between 0.1-15 THz (3–500 cm− 1)
has been underutilised by the biochemistry community but is starting to yield some …

Opalescence in protein solutions reduces aesthetic appeal of a formulation and can be an
indicator of the presence of aggregates or precursor to phase separation in solution …

Adequate stabilization is essential for marketed protein-based biopharmaceutical
formulations to withstand the various stresses that can be exerted during the pre-and post …

Many proteins, especially those used as therapeutics, are unstable to storage and ship**
temperatures, leading to increased costs in research and industry. Therefore, the design and …

Excipients are substances that are added to therapeutic products to improve stability,
bioavailability, and manufacturability. Undesirable protein–protein interactions (PPI) can …