Caenorhabditis elegans has emerged as a major model in biomedical and environmental
toxicology. Numerous papers on toxicology and pharmacology in C. elegans have been …

The maintenance of cellular and organismal homeostasis in the face of changes in the
environment is essential for survival. Pathogenic microorganisms represent one type of …

Distinguishing infectious pathogens from harmless microorganisms is essential for animal
health. The mechanisms used to identify infectious microbes are not fully understood …

Polyphenism is a type of developmental plasticity that translates continuous environmental
variability into discontinuous phenotypes. Such discontinuity likely requires a switch …

Low temperatures delay aging and promote longevity in many organisms. However, the
metabolic and homeostatic aspects of low-temperature–induced longevity remain poorly …

Candidiasis is a multifaceted fungal disease including mucosal-cutaneous, visceral, and
disseminated infections caused by yeast species of the genus Candida. Candida infections …

Fatty acids affect a number of physiological processes, in addition to forming the building
blocks of membranes and body fat stores. In this study, we uncover a role for the …

Highlights•C. elegans detects infection with surveillance or 'effector-triggered'immunity.•
Multiple upstream inputs activate the p38 MAPK pathway.•Autophagy provides defense …

Olfactory neurons allow animals to discriminate nutritious food sources from potential
pathogens. From a forward genetic screen, we uncovered a surprising requirement for the …

Abstract Background 22q11. 2 deletion syndrome (22q11. 2DS) is the most common micro-
deletion syndrome. The associated 22q11. 2 deletion conveys the strongest known …