[HTML][HTML] Oxidative stress and the amyloid beta peptide in Alzheimer's disease
Oxidative stress is known to play an important role in the pathogenesis of a number of
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …
Amyloid β protein and Alzheimer's disease: When computer simulations complement experimental studies
Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
Biological metals and metal-targeting compounds in major neurodegenerative diseases
Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …
Binding of transition metal ions to albumin: sites, affinities and rates
Background Serum albumin is the most abundant protein in the blood and cerebrospinal
fluid and plays a fundamental role in the distribution of essential transition metal ions in the …
fluid and plays a fundamental role in the distribution of essential transition metal ions in the …
Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …
Metal ions and intrinsically disordered proteins and peptides: from Cu/Zn amyloid-β to general principles
Conspectus The interaction of d-block metal ions (Cu, Zn, Fe, etc.) with intrinsically
disordered proteins (IDPs) has gained interest, partly due to their proposed roles in several …
disordered proteins (IDPs) has gained interest, partly due to their proposed roles in several …
Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance
E Atrián-Blasco, P Gonzalez, A Santoro, B Alies… - Coordination chemistry …, 2018 - Elsevier
Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …
their development. This is the case of important neurodegenerative diseases such as …
Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease
Alzheimer's disease is the most common form of age-related neurodegenerative dementia.
The disease is characterised by the presence of plaques in the cerebral cortex. The major …
The disease is characterised by the presence of plaques in the cerebral cortex. The major …
A review on recent advances in amino acid and peptide-based fluorescence and its potential applications
Y **ong, C Shi, L Li, Y Tang, X Zhang, S Liao… - New Journal of …, 2021 - pubs.rsc.org
Fluorescence is widely used to detect functional groups and ions, and peptides are used in
various fields due to their excellent biological activity. In recent years, research on …
various fields due to their excellent biological activity. In recent years, research on …
Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer's disease
Oxidative stress is linked to the etiology of Alzheimer's disease (AD), the most common
cause of dementia in the elderly. Redox active metal ions such as copper catalyze the …
cause of dementia in the elderly. Redox active metal ions such as copper catalyze the …