CD8+ T cells in HIV control, cure and prevention
HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
Impaired HLA class I antigen processing and presentation as a mechanism of acquired resistance to immune checkpoint inhibitors in lung cancer
S Gettinger, J Choi, K Hastings, A Truini, I Datar… - Cancer discovery, 2017 - AACR
Mechanisms of acquired resistance to immune checkpoint inhibitors (ICI) are poorly
understood. We leveraged a collection of 14 ICI-resistant lung cancer samples to investigate …
understood. We leveraged a collection of 14 ICI-resistant lung cancer samples to investigate …
HIV evolution and diversity in ART-treated patients
Characterizing HIV genetic diversity and evolution during antiretroviral therapy (ART)
provides insights into the mechanisms that maintain the viral reservoir during ART. This …
provides insights into the mechanisms that maintain the viral reservoir during ART. This …
Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers
Increasing evidence suggests that durable drug-free control of HIV-1 replication is enabled
by effective cellular immune responses that may induce an attenuated viral reservoir …
by effective cellular immune responses that may induce an attenuated viral reservoir …
Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins
that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner …
that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner …
[HTML][HTML] Impact of early antiretroviral therapy, early life immunity and immune sex differences on HIV disease and posttreatment control in children
Impact of early antiretroviral therapy, early life immunity... : Current Opinion in HIV and AIDS
Impact of early antiretroviral therapy, early life immunity and immune sex differences on HIV …
Impact of early antiretroviral therapy, early life immunity and immune sex differences on HIV …
Regulating inflammation with microbial metabolites
BJ Marsland - Nature medicine, 2016 - nature.com
Regulating inflammation with microbial metabolites | Nature Medicine Skip to main content
Thank you for visiting nature.com. You are using a browser version with limited support for …
Thank you for visiting nature.com. You are using a browser version with limited support for …
Host genetic variation and HIV disease: from map** to mechanism
V Naranbhai, M Carrington - Immunogenetics, 2017 - Springer
This review aims to provide a summary of current knowledge of host genetic effects on
human immunodeficiency virus (HIV) disease. Map** of simple single nucleotide …
human immunodeficiency virus (HIV) disease. Map** of simple single nucleotide …
Ethical considerations in global HIV phylogenetic research
CEM Coltart, A Hoppe, M Parker, L Dawson… - The lancet HIV, 2018 - thelancet.com
Phylogenetic analysis of pathogens is an increasingly powerful way to reduce the spread of
epidemics, including HIV. As a result, phylogenetic approaches are becoming embedded in …
epidemics, including HIV. As a result, phylogenetic approaches are becoming embedded in …
The impact of HIV-1 within-host evolution on transmission dynamics
Highlights•HIV-1 within-host evolution is short-sighted and favours more virulent
viruses.•Systemic HIV-1 infection is mainly established by a single variant …
viruses.•Systemic HIV-1 infection is mainly established by a single variant …