Type 2 diabetes is one of the major chronic diseases accounting for a substantial proportion
of disease burden in Western countries. The majority of the burden of type 2 diabetes is …

Through investigating the combined impact of the environmental exposures experienced by
an individual throughout their lifetime, exposome research provides opportunities to …

Background Cardiovascular disease (CVD) remains a paramount contemporary health
challenge. This study examined age-specific effects of 14 risk factors on CVD and mortality …

The plasma proteome can mediate associations between periodontal disease (Pd) and
brain white matter integrity (WMI). We screened 5089 UK Biobank participants aged 40–70 …

Cardiovascular ageing is a process that begins early in life and leads to a progressive
change in structure and decline in function due to accumulated damage across diverse cell …

Background With two well‐validated aging measures capturing mortality and morbidity risk,
this study examined whether and to what extent aging mediates the associations of …

Background: Pathways explaining racial/ethnic disparities in dementia risk are under-
evaluated. Methods: We examine those disparities and their related pathways among UK …

Background Cardiovascular health is associated with brain magnetic resonance imaging
(MRI) markers of pathology and infections may modulate this association. Methods Using …

Aims Serum sex hormones have been linked to cardiovascular disease risk. However, their
roles in the pathogenesis of heart failure (HF) in both men and women are unclear. We …

The associations between blood pressure and cannabis use remain inconsistent. The
purpose of our study was to examine gender stratified associations of cannabis use and …