Death by TNF: a road to inflammation
Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics
that neutralize TNF are among the most successful drugs for the treatment of chronic …
that neutralize TNF are among the most successful drugs for the treatment of chronic …
Apoptotic cell death in disease—Current understanding of the NCCD 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
SARS-CoV-2 pathogenesis
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …
Innate immunity: the first line of defense against SARS-CoV-2
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …
The development of COVID-19 treatment
Y Yuan, B Jiao, L Qu, D Yang, R Liu - Frontiers in immunology, 2023 - frontiersin.org
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused
a pandemic named coronavirus disease 2019 (COVID-19) that has become the greatest …
a pandemic named coronavirus disease 2019 (COVID-19) that has become the greatest …
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines
The innate immune response is critical for recognizing and controlling infections through the
release of cytokines and chemokines. However, severe pathology during some infections …
release of cytokines and chemokines. However, severe pathology during some infections …
AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence
Inflammasomes are important sentinels of innate immune defence, sensing pathogens and
inducing cell death in infected cells. There are several inflammasome sensors that each …
inducing cell death in infected cells. There are several inflammasome sensors that each …
Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia
Although microbial populations in the gut microbiome are associated with COVID-19
severity, a causal impact on patient health has not been established. Here we provide …
severity, a causal impact on patient health has not been established. Here we provide …