Platelet adhesion, activation and aggregation on the exposed subendothelial extracellular
matrix (ECM) are essential for haemostasis, but may also lead to occlusion of diseased …

Although platelets are best known for their role in hemostasis, they are also crucial in
development, host defense, inflammation, and tissue repair. Many of these roles are …

Deep vein thrombosis (DVT) with its major complication, pulmonary embolism, is a global
health problem. Mechanisms of DVT remain incompletely understood. Platelets play a role …

Platelets play a critical role in maintaining vascular integrity during inflammation, but little is
known about the underlying molecular mechanisms. Here we report that platelet …

Thrombosis is a common, life-threatening consequence of systemic infection; however, the
underlying mechanisms that drive the formation of infection-associated thrombi are poorly …

Essentials• The role of C‐type lectin‐like receptor‐2 (CLEC‐2) in cancer progression is
unclear.• CLEC‐2‐depleted mouse model is generated by using a rat anti‐mouse CLEC‐2 …

Cancer tissues are not just simple masses of malignant cells, but rather complex and
heterogeneous collections of cellular and even non-cellular components, such as …

This chapter summarizes current ideas about the intracellular signaling that drives platelet
responses to vascular injury. After a brief overview of platelet activation intended to place the …

The C-type lectin-like receptor CLEC-2 mediates platelet activation through a hem-
immunoreceptor tyrosine-based activation motif (hemITAM). CLEC-2 initiates a Src-and Syk …

The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on
the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in …