The B rain and B ody D onation P rogram (BBDP) at B anner S un H ealth R esearch I
nstitute (http://www. brainandbodydonationprogram. org) started in 1987 with brain‐only …

Depressive disorders are heterogeneous diseases, and the complexity of symptoms has led
to the formulation of several aethiopathological hypotheses. This heterogeneity may account …

Post-mortem tissues samples are a key resource for investigating patterns of gene
expression. However, the processes triggered by death and the post-mortem interval (PMI) …

Background The use of low quality RNA samples in whole-genome gene expression
profiling remains controversial. It is unclear if transcript degradation in low quality RNA …

Oxidative stress is associated with the progression of Alzheimer's disease (AD). Reactive
oxygen species can modify lipids, DNA, RNA, and proteins in the brain. The products of their …

The development of new treatments for essential tremor, the most frequent movement
disorder, is limited by a poor understanding of its pathophysiology and the relative paucity of …

RNAs are rapidly degraded in samples and during collection, processing and testing. In this
study, we used the same method to explore the half-lives of different RNAs and the …

An estimation of the post mortem interval (PMI) is frequently touted as the Holy Grail of
forensic pathology. During the first hours after death, PMI estimation is dependent on the …

Although the brains of patients with schizophrenia and bipolar disorder exhibit decreased
brain pH relative to those of healthy controls upon postmortem examination, it remains …

Abstract The Brain Donation Program at Sun Health Research Institute has been in
continual operation since 1987, with over 1000 brains banked. The population studied …