MicroRNA-based therapeutics in central nervous system injuries
Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …
Crosstalk of astrocytes and other cells during ischemic stroke
Stroke is a leading cause of death and long-term disability worldwide. Astrocytes structurally
compose tripartite synapses, blood–brain barrier, and the neurovascular unit and perform …
compose tripartite synapses, blood–brain barrier, and the neurovascular unit and perform …
Exosome-mediated crosstalk between keratinocytes and macrophages in cutaneous wound healing
Bidirectional cell–cell communication involving exosome-borne cargo such as miRNA has
emerged as a critical mechanism for wound healing. Unlike other shedding vesicles …
emerged as a critical mechanism for wound healing. Unlike other shedding vesicles …
miR‐29a‐3p in Exosomes from Heme Oxygenase‐1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia‐Reperfusion Injury in Rats …
X Li, L Wu, X Tian, W Zheng, M Yuan… - Oxidative Medicine …, 2022 - Wiley Online Library
Hepatic ischemia‐reperfusion injury (IRI) is an inevitable result of liver surgery. Steatotic
livers are extremely sensitive to IRI and have worse tolerance. Ferroptosis is considered to …
livers are extremely sensitive to IRI and have worse tolerance. Ferroptosis is considered to …
Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue
Although cellular therapies represent a promising strategy for a number of conditions,
current approaches face major translational hurdles, including limited cell sources and the …
current approaches face major translational hurdles, including limited cell sources and the …
Emerging roles of miRNAs in brain development and perinatal brain injury
In human beings the immature brain is highly plastic and depending on the stage of
gestation is particularly vulnerable to a range of insults that if sufficiently severe, can result in …
gestation is particularly vulnerable to a range of insults that if sufficiently severe, can result in …
Mature neurons: equipped for survival
AJ Kole, RP Annis, M Deshmukh - Cell death & disease, 2013 - nature.com
Neurons completely transform how they regulate cell death over the course of their lifetimes.
Develo** neurons freely activate cell death pathways to fine-tune the number of neurons …
Develo** neurons freely activate cell death pathways to fine-tune the number of neurons …
Therapeutic potential of palm oil vitamin E-derived tocotrienols in inflammation and chronic diseases: Evidence from preclinical and clinical studies
Z Zainal, H Khaza'ai, AK Radhakrishnan… - Food Research …, 2022 - Elsevier
Palm oil is rich in tocotrienols (T3s), a type of vitamin E that has garnered considerable
research interest as it exhibits anti-inflammatory as well as antioxidant characteristics that …
research interest as it exhibits anti-inflammatory as well as antioxidant characteristics that …
Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: An integrative review
MJ Millan - Progress in neurobiology, 2017 - Elsevier
The human genome encodes a vast repertoire of protein non-coding RNAs (ncRNA), some
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …
Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke
Stem cell-based treatments have been suggested as promising candidates for stroke.
Recently, mesenchymal stem cells (MSCs) have been reported as potential therapeutics for …
Recently, mesenchymal stem cells (MSCs) have been reported as potential therapeutics for …