MicroRNA-based therapeutics in central nervous system injuries

P Sun, DZ Liu, GC Jickling… - Journal of Cerebral …, 2018 - journals.sagepub.com
Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …

Crosstalk of astrocytes and other cells during ischemic stroke

T He, GY Yang, Z Zhang - Life, 2022 - mdpi.com
Stroke is a leading cause of death and long-term disability worldwide. Astrocytes structurally
compose tripartite synapses, blood–brain barrier, and the neurovascular unit and perform …

Exosome-mediated crosstalk between keratinocytes and macrophages in cutaneous wound healing

X Zhou, BA Brown, AP Siegel, MS El Masry, X Zeng… - ACS …, 2020 - ACS Publications
Bidirectional cell–cell communication involving exosome-borne cargo such as miRNA has
emerged as a critical mechanism for wound healing. Unlike other shedding vesicles …

miR‐29a‐3p in Exosomes from Heme Oxygenase‐1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia‐Reperfusion Injury in Rats …

X Li, L Wu, X Tian, W Zheng, M Yuan… - Oxidative Medicine …, 2022 - Wiley Online Library
Hepatic ischemia‐reperfusion injury (IRI) is an inevitable result of liver surgery. Steatotic
livers are extremely sensitive to IRI and have worse tolerance. Ferroptosis is considered to …

Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue

D Gallego-Pérez, D Pal, S Ghatak, V Malkoc… - Nature …, 2017 - nature.com
Although cellular therapies represent a promising strategy for a number of conditions,
current approaches face major translational hurdles, including limited cell sources and the …

Emerging roles of miRNAs in brain development and perinatal brain injury

KHT Cho, B Xu, C Blenkiron, M Fraser - Frontiers in physiology, 2019 - frontiersin.org
In human beings the immature brain is highly plastic and depending on the stage of
gestation is particularly vulnerable to a range of insults that if sufficiently severe, can result in …

Mature neurons: equipped for survival

AJ Kole, RP Annis, M Deshmukh - Cell death & disease, 2013 - nature.com
Neurons completely transform how they regulate cell death over the course of their lifetimes.
Develo** neurons freely activate cell death pathways to fine-tune the number of neurons …

Therapeutic potential of palm oil vitamin E-derived tocotrienols in inflammation and chronic diseases: Evidence from preclinical and clinical studies

Z Zainal, H Khaza'ai, AK Radhakrishnan… - Food Research …, 2022 - Elsevier
Palm oil is rich in tocotrienols (T3s), a type of vitamin E that has garnered considerable
research interest as it exhibits anti-inflammatory as well as antioxidant characteristics that …

Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: An integrative review

MJ Millan - Progress in neurobiology, 2017 - Elsevier
The human genome encodes a vast repertoire of protein non-coding RNAs (ncRNA), some
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …

Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke

A Rahmani, K Saleki, N Javanmehr… - Ageing research …, 2020 - Elsevier
Stem cell-based treatments have been suggested as promising candidates for stroke.
Recently, mesenchymal stem cells (MSCs) have been reported as potential therapeutics for …