TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …

Alzheimer's disease (AD) is the sixth leading cause of death in the United States and the
most common cause of dementia in the elderly. Genetic factors, such as rare variants in the …

The protein triggering receptor expressed on myeloid cells-2 (TREM2) is an
immunomodulatory receptor with a central role in myeloid cell activation and survival. In …

Alzheimer's disease (AD), the most common cause of dementia in the elderly, is a complex
neurodegenerative disease marked by the appearance of amyloid-β (Aβ) plaques and …

Prion diseases are a group of progressive and fatal neurodegenerative disorders
characterized by deposition of scrapie prion protein (PrPSc) in the CNS. This deposition is …

Background Prion diseases and prion-like disorders, including Alzheimer's disease and
Parkinson's disease, are characterized by gliosis and accumulation of misfolded aggregated …

Chronic neuroinflammation is recognized as a major neuropathological hallmark in a broad
spectrum of neurodegenerative diseases including Alzheimer's, Parkinson's, Frontal …

Objective To investigate the association between serum soluble triggering receptor
expressed on myeloid cells 2 (sTREM2), a soluble type of an innate immune receptor …

Neuroinflammation, typically manifest as microglial activation and astrogliosis accompanied
by transcriptomic alterations, represents a common hallmark of various neurodegenerative …

Prion diseases are neurodegenerative diseases that affect humans and animals. They are
always fatal and, to date, no treatment exists. The hallmark of prion disease pathophysiology …