Clinical and neuropathogenetic aspects of human African trypanosomiasis

PGE Kennedy, J Rodgers - Frontiers in immunology, 2019 - frontiersin.org
Trypanosomiasis has been recognized as a scourge in sub-Saharan Africa for centuries.
The disease, caused by protozoan parasites of the Trypanosoma genus, is a major cause of …

The pathogenesis of African trypanosomiasis

E Pays, M Radwanska, S Magez - Annual Review of Pathology …, 2023 - annualreviews.org
African trypanosomes are bloodstream protozoan parasites that infect mammals including
humans, where they cause slee** sickness. Long-lasting infection is required to favor …

The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity–a tale of conflict and conundrum

M Müller, S Carter, MJ Hofer… - Neuropathology and …, 2010 - Wiley Online Library
M. Müller, S. Carter, MJ Hofer and IL Campbell (2010) Neuropathology and Applied
Neurobiology36, 368–387 The chemokine receptor CXCR3 and its ligands CXCL9 …

The central role of hypothalamic inflammation in the acute illness response and cachexia

KG Burfeind, KA Michaelis, DL Marks - Seminars in cell & developmental …, 2016 - Elsevier
When challenged with a variety of inflammatory threats, multiple systems across the body
undergo physiological responses to promote defense and survival. The constellation of …

CXCL10 triggers early microglial activation in the cuprizone model

T Clarner, K Janssen, L Nellessen… - The Journal of …, 2015 - journals.aai.org
A broad spectrum of diseases is characterized by myelin abnormalities and/or
oligodendrocyte pathology. In most, if not all, of these diseases, early activation of microglia …

Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to Pathogenicity

B Stijlemans, G Caljon, J Van Den Abbeele… - Frontiers in …, 2016 - frontiersin.org
The diseases caused by African trypanosomes (AT) are of both medical and veterinary
importance and have adversely influenced the economic development of sub-Saharan …

IP-10 promotes blood–brain barrier damage by inducing tumor necrosis factor alpha production in Japanese encephalitis

K Wang, H Wang, W Lou, L Ma, Y Li, N Zhang… - Frontiers in …, 2018 - frontiersin.org
Japanese encephalitis is a neuropathological disorder caused by Japanese encephalitis
virus (JEV), which is characterized by severe pathological neuroinflammation and damage …

Adipose tissue: a safe haven for parasites?

HB Tanowitz, PE Scherer, MM Mota… - Trends in parasitology, 2017 - cell.com
Adipose tissue (AT) is no longer regarded as an inert lipid storage, but as an important
central regulator in energy homeostasis and immunity. Three parasite species are uniquely …

African trypanosome infections of the nervous system: parasite entry and effects on sleep and synaptic functions

K Kristensson, M Nygård, G Bertini… - Progress in …, 2010 - Elsevier
The extracellular parasite Trypanosoma brucei causes human African trypanosomiasis
(HAT), also known as slee** sickness. Trypanosomes are transmitted by tsetse flies and …

Microbes' roadmap to neurons

K Kristensson - Nature Reviews Neuroscience, 2011 - nature.com
The nervous system is protected by barriers that restrict the invasion of pathogens.
Nevertheless, mechanisms have evolved by which microbes can pass these barriers, enter …