Genetics of structural and functional brain changes in autism spectrum disorder

S Hashem, S Nisar, AA Bhat, SK Yadav… - Translational …, 2020 - nature.com
Autism spectrum disorder (ASD) is a neurological and developmental disorder characterized
by social impairment and restricted interactive and communicative behaviors. It may occur …

Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder

S Nisar, M Haris - Molecular psychiatry, 2023 - nature.com
Autism-spectrum disorders (ASDs) are developmental disabilities that manifest in early
childhood and are characterized by qualitative abnormalities in social behaviors …

Roles of the oxytocin receptor (OXTR) in human diseases

K Pierzynowska, L Gaffke, M Żabińska, Z Cyske… - International journal of …, 2023 - mdpi.com
The oxytocin receptor (OXTR), encoded by the OXTR gene, is responsible for the signal
transduction after binding its ligand, oxytocin. Although this signaling is primarily involved in …

Oxytocin receptor gene (OXTR) polymorphisms and social, emotional and behavioral functioning in children and adolescents: A systematic narrative review

J Kohlhoff, S Cibralic, DJ Hawes, V Eapen - Neuroscience & Biobehavioral …, 2022 - Elsevier
This study systematically reviewed available evidence regarding associations between
polymorphisms of the oxytocin receptor (OXTR) gene and socio-emotional and behavioral …

A systematic review of common genetic variation and biological pathways in autism spectrum disorder

DA Rodriguez-Gomez, DP Garcia-Guaqueta… - BMC neuroscience, 2021 - Springer
Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition
characterized by persistent deficits in social communication and interaction. Common …

[HTML][HTML] Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies

EJ Kraaijenvanger, Y He, H Spencer, AK Smith… - Neuroscience & …, 2019 - Elsevier
The human oxytocin (OXT) system is implicated in the regulation of complex social
behaviors, as well as in psychopathologies characterized by social deficits. Emerging …

[HTML][HTML] Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells

ACM Couch, S Solomon, RRR Duarte… - Brain, Behavior, and …, 2023 - Elsevier
Background Prenatal exposure to elevated interleukin (IL)-6 levels is associated with
increased risk for psychiatric disorders with a putative neurodevelopmental origin, such as …

Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits–A systematic review

M Moerkerke, ML Bonte, N Daniels, V Chubar… - Research in Autism …, 2021 - Elsevier
There is emerging evidence implicating oxytocin receptor gene (OXTR) DNA methylation
(DNAm) in social behaviour. This review investigated its association with autism spectrum …

Gut microbiota metabolites in autistic children: An epigenetic perspective

H Sabit, H Tombuloglu, S Rehman, NB Almandil… - Heliyon, 2021 - cell.com
Gut microbiota has become an issue of great importance recently due to its major role in
autism spectrum disorder (ASD). Over the past three decades, there has been a sustained …

Synthesis of genetic association studies on autism spectrum disorders using a genetic model-free approach

I Mpoulimari, E Zintzaras - Psychiatric genetics, 2022 - journals.lww.com
Background Autism spectrum disorder (ASD) is a clinically and genetically heterogeneous
group of neurodevelopmental disorders. Despite the extensive efforts of scientists, the …