Heavy-ion induced chromosomal aberrations: a review

S Ritter, M Durante - Mutation Research/Genetic Toxicology and …, 2010 - Elsevier
Heavy-ion radiobiology is attracting increasing interest for its implications in radiation
oncology and space radiation protection. The analysis of chromosome aberrations induced …

Particles with similar LET values generate DNA breaks of different complexity and reparability: a high-resolution microscopy analysis of γH2AX/53BP1 foci

L Jezkova, M Zadneprianetc, E Kulikova, E Smirnova… - Nanoscale, 2018 - pubs.rsc.org
Biological effects of high-LET (linear energy transfer) radiation have received increasing
attention, particularly in the context of more efficient radiotherapy and space exploration …

Radiation Leukemogenesis in Mice: Loss of PU.1 on Chromosome 2 in CBA and C57BL/6 Mice after Irradiation with 1 GeV/nucleon 56Fe Ions, X Rays or γ Rays …

Y Peng, N Brown, R Finnon, CL Warner… - Radiation …, 2009 - meridian.allenpress.com
Abstract Peng, Y., Brown, N., Finnon, R., Warner, CL, Liu, X., Genik, PC, Callan, MA, Ray,
FA, Borak, TB, Badie, C., Bouffler, SD, Ullrich, RL, Bedford, JS and Weil, MM Radiation …

Chromosome aberration yields and apoptosis in human lymphocytes irradiated with Fe-ions of differing LET

R Lee, E Nasonova, S Ritter - Advances in Space Research, 2005 - Elsevier
In the present paper the relationship between cell cycle delays induced by Fe-ions of
differing LET and the aberration yield observable in human lymphocytes at mitosis was …

Complex exchanges are responsible for the increased effectiveness of C-ions compared to X-rays at the first post-irradiation mitosis

R Lee, S Sommer, C Hartel, E Nasonova… - … /Genetic Toxicology and …, 2010 - Elsevier
The purpose of the present study was to investigate as to what extent differences in the
linear energy transfer (LET) are reflected at the chromosomal level. For this study human …

[HTML][HTML] Relative proximity of chromosome territories influences chromosome exchange partners in radiation-induced chromosome rearrangements in primary human …

HA Foster, G Estrada-Girona, M Themis… - … /Genetic Toxicology and …, 2013 - Elsevier
It is well established that chromosomes exist in discrete territories (CTs) in interphase and
are positioned in a cell-type specific probabilistic manner. The relative localisation of …

Cell killing, nuclear damage and apoptosis in Chinese hamster V79 cells after irradiation with heavy-ion beams of 16O, 12C and 7Li

R Pathak, SK Dey, A Sarma… - Mutation Research/Genetic …, 2007 - Elsevier
Chinese hamster V79 cells were exposed to high LET (linear energy transfer) 16O-beam
(625keV/μm) radiation in the dose range of 0–9.83 Gy. Cell survival, micronuclei (MN) …

Biological effectiveness of accelerated particles for the induction of chromosome damage: track structure effects

KA George, M Hada, L Chappell… - Radiation …, 2013 - meridian.allenpress.com
We have investigated how radiation quality affects the induction of chromosomal aberrations
in human cells. Human lymphocytes were irradiated in vitro with various energies of …

Role of DNA-PK in the process of aberration formation as studied in irradiated human glioblastoma cell lines M059K and M059J

P Virsik-Koepp, M Rave-Fraenk… - … journal of radiation …, 2003 - Taylor & Francis
Purpose: The participation of various DNA double-strand break repair mechanisms in the
formation of chromosome aberrations is not yet fully understood. To investigate particularly …

Relationship between aberration yield and mitotic delay in human lymphocytes exposed to 200 MeV/u Fe-ions or X-rays

S Ritter, E Nasonova, Y Furusawa… - Journal of radiation …, 2002 - jstage.jst.go.jp
The time-course of Fe-ion (200 MeV/u, 440 keV/µm) and X-ray induced chromosomal
damage was investigated in human lymphocytes. After cells were exposed in G0 and …