Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and
extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs …

Abstract Development and disease are regulated by the interplay between genetics and the
signaling pathways stimulated by morphogens, growth factors, and cytokines. Experimental …

The onset, development, diagnosis, and treatment of cancer involve intricate interactions
among various factors, spanning the realms of mechanics, physics, chemistry, and biology …

Tumor cells metastasize to distant organs mainly via hematogenous dissemination, in which
circulating tumor cells (CTCs) are relatively vulnerable, and eliminating these cells has great …

To seed lethal secondary lesions, circulating tumor cells (CTCs) must survive all rate-limiting
factors during hematogenous dissemination, including fluid shear stress (FSS) that poses a …

Distant metastasis mainly occurs through hematogenous dissemination, where suspended
circulating tumor cells (CTCs) experience a considerable level of fluid shear stress. We …

The influence of Poiseuille flow on cell viability has applications in the areas of cancer
metastasis, lab-on-a-chip devices and flow cytometry. Indeed, retaining cell viability is …

Simple Summary Cancer cell dissemination exhibits organ preference or organotropism.
Although the influence of intrinsic biochemical factors on organotropism has been intensely …

Cancer stem cells (CSCs) have been believed to be one driving force for tumor progression
and drug resistance. Despite the significance of biochemical signaling in malignancy, highly …

As the driving force of tumor progression, cancer stem cells (CSCs) hold much lower cellular
stiffness than bulk tumor cells across many cancer types. However, it remains unclear …