The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …

Breast cancer has grown to be the second leading cause of cancer-related deaths in
women. Only a few treatment options are available for breast cancer due to the widespread …

Cancer stem cells (CSCs) represent a tumor subpopulation responsible for tumor metastasis
and resistance to chemo-and radiotherapy, ultimately leading to tumor relapse. As a …

The emerging concept of cancer stem cells (CSCs) as the key driver behind carcinogenesis,
progression, and diversity has displaced the prior model of a tumor composed of cells with …

Tumors consist of heterogeneous cell populations, and tumor heterogeneity plays key roles
in regulating tumorigenesis, metastasis, recurrence and resistance to anti-tumor therapies …

Leukemia inhibitory factor (LIF), and its receptor (LIFR), are commonly over-expressed in
many solid cancers and recent studies have implicated LIF/LIFR axis as a promising clinical …

Pattern-recognition receptors (PRRs) are critical to recognizing endogenous and exogenous
threats to mount a protective proinflammatory innate immune response. PRRs may be …

Breast cancer is the most common form of tumor in women and the leading cause of cancer-
related mortality. Even though the major cellular burden in breast cancer is constituted by …

Rationale: Metastasis is a complex process with a molecular underpinning that remains
unclear. We hypothesize that cargo proteins conducted by extracellular vesicles (EVs) …

Breast cancer (BC) is one of the most common malignant tumors in women globally, and its
occurrence has surpassed lung cancer and become the biggest threat for women. At …