Functionalizing DNA origami to investigate and interact with biological systems
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …
dynamic properties and nanoscale control. These nanostructures enable complex …
Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation
KA Afonin, MA Dobrovolskaia, W Ke… - Advanced drug delivery …, 2022 - Elsevier
With numerous recent advances, the field of therapeutic nucleic acid nanotechnology is now
poised for clinical translation supported by several examples of FDA-approved nucleic acid …
poised for clinical translation supported by several examples of FDA-approved nucleic acid …
[HTML][HTML] Data-driven design and morphological analysis of conical six-fold origami structures
In engineering design, origami structures are frequently characterized by their geometry-
shifting behavior, mechanical properties, lightness, and appealing aesthetic qualities. In …
shifting behavior, mechanical properties, lightness, and appealing aesthetic qualities. In …
Innate immune stimulation using 3D wireframe DNA origami
Three-dimensional wireframe DNA origami have programmable structural and sequence
features that render them potentially suitable for prophylactic and therapeutic applications …
features that render them potentially suitable for prophylactic and therapeutic applications …
Ultrafast dense DNA functionalization of quantum dots and rods for scalable 2D array fabrication with nanoscale precision
Scalable fabrication of two-dimensional (2D) arrays of quantum dots (QDs) and quantum
rods (QRs) with nanoscale precision is required for numerous device applications. However …
rods (QRs) with nanoscale precision is required for numerous device applications. However …
Nanoscale 3D spatial addressing and valence control of quantum dots using wireframe DNA origami
Control over the copy number and nanoscale positioning of quantum dots (QDs) is critical to
their application to functional nanomaterials design. However, the multiple non-specific …
their application to functional nanomaterials design. However, the multiple non-specific …
Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds
Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize
antigens and enhance humoral immunity through multivalent antigen display. However, P …
antigens and enhance humoral immunity through multivalent antigen display. However, P …
Programming 2D supramolecular assemblies with wireframe DNA origami
Wireframe DNA origami offers the ability to program nearly arbitrary 2D and 3D nanoscale
geometries, with six-helix bundle (6HB) edge designs providing both geometric versatility …
geometries, with six-helix bundle (6HB) edge designs providing both geometric versatility …
Evaluation of nonmodified wireframe DNA origami for acute toxicity and biodistribution in mice
EC Wamhoff, GA Knappe, AA Burds… - ACS applied bio …, 2023 - ACS Publications
Wireframe DNA origami can be used to fabricate virus-like particles for a range of
biomedical applications, including the delivery of nucleic acid therapeutics. However, the …
biomedical applications, including the delivery of nucleic acid therapeutics. However, the …
Controlling nuclease degradation of wireframe DNA origami with minor groove binders
Viruslike particles (VLPs) fabricated using wireframe DNA origami are emerging as
promising vaccine and gene therapeutic delivery platforms due to their programmable …
promising vaccine and gene therapeutic delivery platforms due to their programmable …