Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …

Platinum drugs are extensively used in the clinic to treat cancer, often leading to a palliative
response rather than a cure. While DNA is considered to be the primary target of platinum …

Background Cisplatin (CDDP) treatment is one of the most predominant chemotherapeutic
strategies for patients with gastric cancer (GC). A better understanding of the mechanisms of …

Tumor-associated macrophages (TAM) promote triple-negative breast cancer (TNBC)
progression. Here, we report BRCA1-IRIS–overexpressing (IRISOE) TNBC cells secrete …

Small cell lung cancer (SCLC) is an aggressive malignancy characterized by early
metastasis and extreme lethality. The backbone of SCLC treatment over the past several …

Ovarian high-grade serous carcinoma (HGSC) is the most common subtype of ovarian
cancer with limited therapeutic options and a poor prognosis. In recent years, poly-ADP …

Abstract m6A (N6-methyladenosine) methylation, a well-known modification in tumour
epigenetics, dynamically and reversibly fine tunes the entire process of RNA metabolism …

Cancer is caused by malfunctioning of genes that normally regulate cardinal processes
including various nuclear functions, cell division and survival, cell surface to nucleus …

BRCA1 and BRCA2 are multi-functional proteins and key factors for maintaining genomic
stability through their roles in DNA double strand break repair by homologous …

Ovarian cancer accounts for the highest mortality among all gynecologic cancers.
Cytoreductive surgery followed by chemotherapy with a platinum-based agent (cisplatin or …