This review is a short update on the diversity of swine biomedical models and the
importance of genomics in their continued development. The swine has been used as a …

Within the sperm nucleus the paternal genome remains functionally inert and protected
following protamination. This is marked by a structural morphogenesis that is heralded by a …

Spermatogonial stem cells exhibit a low level of spontaneous mutation that is heavily
impacted by paternal age via mechanisms that appear to involve the aberrant repair of DNA …

Chromosomal translocations and genomic instability are universal hallmarks of tumor cells.
While the molecular mechanisms leading to the formation of translocations are rapidly being …

Background Radial chromosome positioning in interphase nuclei is nonrandom and can
alter according to developmental, differentiation, proliferation, or disease status. However, it …

Genomes are housed within cell nuclei as individual chromosome territories. Nuclei contain
several architectural structures that interact and influence the genome. In this review, we …

A multitude of biochemical signaling processes have been characterized that affect gene
expression and cellular activity. However, living cells often need to integrate biochemical …

Sperm present a highly particular DNA condensation that is acquired during their
differentiation. Protamines are key elements for DNA condensation. However, whereas the …

The inner face of the nuclear envelope of metazoan cells is covered by a thin lamina
consisting of a one‐layered network of intermediate filaments interconnecting with a …

The mammalian genome is highly organized within the cell nucleus. The nuclear position of
many genes and genomic regions changes during physiological processes such as …