Fibroblast growth factor in diabetic foot ulcer: progress and therapeutic prospects

Y Liu, Y Liu, J Deng, W Li, X Nie - Frontiers in endocrinology, 2021 - frontiersin.org
Diabetic foot ulcer (DFU) is a combination of neuropathy and various degrees of peripheral
vasculopathy in diabetic patients resulting in lower extremity infection, ulcer formation, and …

[HTML][HTML] Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

AL Cardoso, A Fernandes, JA Aguilar-Pimentel… - Ageing research …, 2018 - Elsevier
Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

[HTML][HTML] Retinopathy of prematurity: A review of pathophysiology and signaling pathways

M Fevereiro-Martins, C Marques-Neves… - survey of …, 2023 - Elsevier
Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading
cause of visual impairment and childhood blindness worldwide. The disease is …

Targeting FGF21 in cardiovascular and metabolic diseases: from mechanism to medicine

H Tan, T Yue, Z Chen, W Wu, S Xu… - International Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Cardiovascular and metabolic disease (CVMD) is becoming increasingly prevalent in
developed and develo** countries with high morbidity and mortality. In recent years …

Photoreceptor cells and RPE contribute to the development of diabetic retinopathy

D Tonade, TS Kern - Progress in retinal and eye research, 2021 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as
vascular disease, but work in the past years has shown abnormalities also in the neural …

Diabetic retinopathy: Involved cells, biomarkers, and treatments

J Ren, S Zhang, Y Pan, M **, J Li, Y Luo… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy (DR), a leading cause of vision loss and blindness worldwide, is
caused by retinal neurovascular unit dysfunction, and its cellular pathology involves at least …

Contribution of Müller cells in the diabetic retinopathy development: focus on oxidative stress and inflammation

R Carpi-Santos, RA de Melo Reis, FCA Gomes… - Antioxidants, 2022 - mdpi.com
Diabetic retinopathy is a neurovascular complication of diabetes and the main cause of
vision loss in adults. Glial cells have a key role in maintenance of central nervous system …

New developments in the biology of fibroblast growth factors

DM Ornitz, N Itoh - WIREs mechanisms of disease, 2022 - Wiley Online Library
The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Dyslipidemia in retinal metabolic disorders

Z Fu, CT Chen, G Cagnone, E Heckel… - EMBO Molecular …, 2019 - embopress.org
The light‐sensitive photoreceptors in the retina are extremely metabolically demanding and
have the highest density of mitochondria of any cell in the body. Both physiological and …

Retinopathy of prematurity: Metabolic risk factors

Z Fu, AK Nilsson, A Hellstrom, LEH Smith - Elife, 2022 - elifesciences.org
At preterm birth, the retina is incompletely vascularized. Retinopathy of prematurity (ROP) is
initiated by the postnatal suppression of physiological retinal vascular development that …