Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

Lysosomes are degradation centers and signaling hubs in cells and play important roles in
cellular homeostasis, development, and aging. Changes in lysosome function are essential …

Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among
which the function of GSDMC has not been clearly described. Herein, we demonstrate that …

In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

Lysosomal storage diseases are a group of metabolic disorders caused by deficiencies of
several components of lysosomal function. Most commonly affected are lysosomal …

Lysosomes are catabolic organelles that contribute to the degradation of intracellular
constituents through autophagy and of extracellular components through endocytosis …

Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …

Lysosomes are in the center of the cellular control of catabolic and anabolic processes.
These membrane-surrounded acidic organelles contain around 70 hydrolases, 200 …

Tumour cells under hypoxia tend to modulate the number and contents of extracellular
vesicles (EVs) to regulate the tumour microenvironment (TME) and thus promote tumour …

Betulinic acid (BA) is a pentacyclic triterpene compound that can be obtained by separation,
chemical synthesis and biotransformation from birch. BA has antitumour activity, and its …