Design, implementation and evaluation of a practical pseudoknot folding algorithm based on thermodynamics

J Reeder, R Giegerich - BMC bioinformatics, 2004 - Springer
Background The general problem of RNA secondary structure prediction under the widely
used thermodynamic model is known to be NP-complete when the structures considered …

Fatgraph models of RNA structure

F Huang, C Reidys, R Rezazadegan - … and Mathematical Biophysics, 2017 - degruyter.com
In this review paper we discuss fatgraphs as a conceptual framework for RNA structures. We
discuss various notions of coarse-grained RNA structures and relate them to fatgraphs. We …

Topology and prediction of RNA pseudoknots

CM Reidys, FWD Huang, JE Andersen… - …, 2011 - academic.oup.com
Motivation: Several dynamic programming algorithms for predicting RNA structures with
pseudoknots have been proposed that differ dramatically from one another in the classes of …

A graph theoretical approach for predicting common RNA secondary structure motifs including pseudoknots in unaligned sequences

Y Ji, X Xu, GD Stormo - Bioinformatics, 2004 - academic.oup.com
Motivation: RNA structure motifs contained in mRNAs have been found to play important
roles in regulating gene expression. However, identification of novel RNA regulatory motifs …

DotKnot: pseudoknot prediction using the probability dot plot under a refined energy model

J Sperschneider, A Datta - Nucleic acids research, 2010 - academic.oup.com
ABSTRACT RNA pseudoknots are functional structure elements with key roles in viral and
cellular processes. Prediction of a pseudoknotted minimum free energy structure is an NP …

SimulFold: simultaneously inferring RNA structures including pseudoknots, alignments, and trees using a Bayesian MCMC framework

IM Meyer, I Miklós - PLoS computational biology, 2007 - journals.plos.org
Computational methods for predicting evolutionarily conserved rather than thermodynamic
RNA structures have recently attracted increased interest. These methods are indispensable …

Grammatical inference in bioinformatics

Y Sakakibara - IEEE Transactions on Pattern Analysis and …, 2005 - ieeexplore.ieee.org
Bioinformatics is an active research area aimed at develo** intelligent systems for
analyses of molecular biology. Many methods based on formal language theory, statistical …

[PDF][PDF] Computational RNA structure prediction

E Capriotti, MA Marti-Renom - Curr. Bioinform, 2008 - biofold.github.io
The view of RNA as simple information transfer molecule has been continuously challenged
since the discovery of ribozymes, a class of RNA molecules with enzyme-like function …

A heuristic approach for detecting RNA H-type pseudoknots

CH Huang, CL Lu, HT Chiu - Bioinformatics, 2005 - academic.oup.com
Motivation RNA H-type pseudoknots are ubiquitous pseudoknots that are found in almost all
classes of RNA and thought to play very important roles in a variety of biological processes …

Predicting RNA secondary structures with pseudoknots by MCMC sampling

D Metzler, ME Nebel - Journal of mathematical biology, 2008 - Springer
The most probable secondary structure of an RNA molecule, given the nucleotide sequence,
can be computed efficiently if a stochastic context-free grammar (SCFG) is used as the prior …