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Design, implementation and evaluation of a practical pseudoknot folding algorithm based on thermodynamics
Background The general problem of RNA secondary structure prediction under the widely
used thermodynamic model is known to be NP-complete when the structures considered …
used thermodynamic model is known to be NP-complete when the structures considered …
Fatgraph models of RNA structure
In this review paper we discuss fatgraphs as a conceptual framework for RNA structures. We
discuss various notions of coarse-grained RNA structures and relate them to fatgraphs. We …
discuss various notions of coarse-grained RNA structures and relate them to fatgraphs. We …
Topology and prediction of RNA pseudoknots
Motivation: Several dynamic programming algorithms for predicting RNA structures with
pseudoknots have been proposed that differ dramatically from one another in the classes of …
pseudoknots have been proposed that differ dramatically from one another in the classes of …
A graph theoretical approach for predicting common RNA secondary structure motifs including pseudoknots in unaligned sequences
Y Ji, X Xu, GD Stormo - Bioinformatics, 2004 - academic.oup.com
Motivation: RNA structure motifs contained in mRNAs have been found to play important
roles in regulating gene expression. However, identification of novel RNA regulatory motifs …
roles in regulating gene expression. However, identification of novel RNA regulatory motifs …
DotKnot: pseudoknot prediction using the probability dot plot under a refined energy model
ABSTRACT RNA pseudoknots are functional structure elements with key roles in viral and
cellular processes. Prediction of a pseudoknotted minimum free energy structure is an NP …
cellular processes. Prediction of a pseudoknotted minimum free energy structure is an NP …
SimulFold: simultaneously inferring RNA structures including pseudoknots, alignments, and trees using a Bayesian MCMC framework
IM Meyer, I Miklós - PLoS computational biology, 2007 - journals.plos.org
Computational methods for predicting evolutionarily conserved rather than thermodynamic
RNA structures have recently attracted increased interest. These methods are indispensable …
RNA structures have recently attracted increased interest. These methods are indispensable …
Grammatical inference in bioinformatics
Y Sakakibara - IEEE Transactions on Pattern Analysis and …, 2005 - ieeexplore.ieee.org
Bioinformatics is an active research area aimed at develo** intelligent systems for
analyses of molecular biology. Many methods based on formal language theory, statistical …
analyses of molecular biology. Many methods based on formal language theory, statistical …
[PDF][PDF] Computational RNA structure prediction
The view of RNA as simple information transfer molecule has been continuously challenged
since the discovery of ribozymes, a class of RNA molecules with enzyme-like function …
since the discovery of ribozymes, a class of RNA molecules with enzyme-like function …
A heuristic approach for detecting RNA H-type pseudoknots
CH Huang, CL Lu, HT Chiu - Bioinformatics, 2005 - academic.oup.com
Motivation RNA H-type pseudoknots are ubiquitous pseudoknots that are found in almost all
classes of RNA and thought to play very important roles in a variety of biological processes …
classes of RNA and thought to play very important roles in a variety of biological processes …
Predicting RNA secondary structures with pseudoknots by MCMC sampling
D Metzler, ME Nebel - Journal of mathematical biology, 2008 - Springer
The most probable secondary structure of an RNA molecule, given the nucleotide sequence,
can be computed efficiently if a stochastic context-free grammar (SCFG) is used as the prior …
can be computed efficiently if a stochastic context-free grammar (SCFG) is used as the prior …