Deep learning-enabled virtual histological staining of biological samples

B Bai, X Yang, Y Li, Y Zhang, N Pillar… - Light: Science & …, 2023 - nature.com
Histological staining is the gold standard for tissue examination in clinical pathology and life-
science research, which visualizes the tissue and cellular structures using chromatic dyes or …

Roadmap on Label‐Free Super‐Resolution Imaging

VN Astratov, YB Sahel, YC Eldar… - Laser & Photonics …, 2023 - Wiley Online Library
Label‐free super‐resolution (LFSR) imaging relies on light‐scattering processes in
nanoscale objects without a need for fluorescent (FL) staining required in super‐resolved FL …

[HTML][HTML] Deep learning-based transformation of H&E stained tissues into special stains

K de Haan, Y Zhang, JE Zuckerman, T Liu… - Nature …, 2021 - nature.com
Pathology is practiced by visual inspection of histochemically stained tissue slides. While the
hematoxylin and eosin (H&E) stain is most commonly used, special stains can provide …

Deep learning-based virtual staining, segmentation, and classification in label-free photoacoustic histology of human specimens

C Yoon, E Park, S Misra, JY Kim, JW Baik… - Light: Science & …, 2024 - nature.com
In pathological diagnostics, histological images highlight the oncological features of excised
specimens, but they require laborious and costly staining procedures. Despite recent …

Accelerating histopathology workflows with generative AI-based virtually multiplexed tumour profiling

P Pati, S Karkampouna, F Bonollo… - Nature machine …, 2024 - nature.com
Understanding the spatial heterogeneity of tumours and its links to disease initiation and
progression is a cornerstone of cancer biology. Presently, histopathology workflows heavily …

Virtual birefringence imaging and histological staining of amyloid deposits in label-free tissue using autofluorescence microscopy and deep learning

X Yang, B Bai, Y Zhang, M Aydin, Y Li… - Nature …, 2024 - nature.com
Systemic amyloidosis involves the deposition of misfolded proteins in organs/tissues,
leading to progressive organ dysfunction and failure. Congo red is the gold-standard …

[HTML][HTML] Application of machine learning in 3D bioprinting: focus on development of big data and digital twin

J An, CK Chua, V Mironov - International journal of bioprinting, 2021 - ncbi.nlm.nih.gov
The application of machine learning (ML) in bioprinting has attracted considerable attention
recently. Many have focused on the benefits and potential of ML, but a clear overview of how …

Deep learning for biospectroscopy and biospectral imaging: state-of-the-art and perspectives

H He, S Yan, D Lyu, M Xu, R Ye, P Zheng, X Lu… - 2021 - ACS Publications
With the advances in instrumentation and sampling techniques, there is an explosive growth
of data from molecular and cellular samples. The call to extract more information from the …

Biopsy-free in vivo virtual histology of skin using deep learning

J Li, J Garfinkel, X Zhang, D Wu, Y Zhang… - Light: Science & …, 2021 - nature.com
An invasive biopsy followed by histological staining is the benchmark for pathological
diagnosis of skin tumors. The process is cumbersome and time-consuming, often leading to …

Misalignment resilient diffractive optical networks

D Mengu, Y Zhao, NT Yardimci, Y Rivenson… - …, 2020 - degruyter.com
As an optical machine learning framework, Diffractive Deep Neural Networks (D2NN) take
advantage of data-driven training methods used in deep learning to devise light–matter …