Metabolic heterogeneity in cancer
Cancer cells rewire their metabolism to survive during cancer progression. In this context,
tumour metabolic heterogeneity arises and develops in response to diverse environmental …
tumour metabolic heterogeneity arises and develops in response to diverse environmental …
Metabolic and signaling roles of ketone bodies in health and disease
Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …
[HTML][HTML] Ketogenic diet in the treatment of cancer–where do we stand?
Background Cancer is one of the greatest public health challenges worldwide, and we still
lack complementary approaches to significantly enhance the efficacy of standard anticancer …
lack complementary approaches to significantly enhance the efficacy of standard anticancer …
Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics
Ketone body metabolism is a central node in physiological homeostasis. In this review, we
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …
The cancer metabolic reprogramming and immune response
L ** metabolic reprogramming of cancer and immune cells is a putative
determinant of the antitumor immune response in cancer. Increased evidence suggests that …
determinant of the antitumor immune response in cancer. Increased evidence suggests that …
Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect
L Sun, C Suo, S Li, H Zhang, P Gao - … et Biophysica Acta (BBA)-Reviews on …, 2018 - Elsevier
While metabolic reprogramming of cancer cells has long been considered from the
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …
Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas
Q Zhang, Y Lou, J Yang, J Wang, J Feng, Y Zhao… - Gut, 2019 - gut.bmj.com
Objective Hepatocellular carcinoma (HCC) is heterogeneous, especially in multifocal
tumours, which decreases the efficacy of clinical treatments. Understanding tumour …
tumours, which decreases the efficacy of clinical treatments. Understanding tumour …
OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB
Metabolic reprogramming is an important feature of cancers that has been closely linked to
post-translational protein modification (PTM). Lysine succinylation is a recently identified …
post-translational protein modification (PTM). Lysine succinylation is a recently identified …
Cancer metabolism and tumor microenvironment: fostering each other?
The changes associated with malignancy are not only in cancer cells but also in
environment in which cancer cells live. Metabolic reprogramming supports tumor cell high …
environment in which cancer cells live. Metabolic reprogramming supports tumor cell high …
Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development
L Wilde, M Roche, M Domingo-Vidal, K Tanson… - Seminars in …, 2017 - Elsevier
abstract Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …