Targeted drug delivery with polymers and magnetic nanoparticles: covalent and noncovalent approaches, release control, and clinical studies

K Ulbrich, K Hola, V Subr, A Bakandritsos… - Chemical …, 2016 - ACS Publications
Targeted delivery combined with controlled drug release has a pivotal role in the future of
personalized medicine. This review covers the principles, advantages, and drawbacks of …

Drug delivery and targeting.

R Langer - Nature, 1998 - europepmc.org
When a pharmaceutical agent is encapsulated within, or attached to, a polymer or lipid, drug
safety and efficacy can be greatly improved and new therapies are possible. This has …

Polymeric conjugates for drug delivery

N Larson, H Ghandehari - Chemistry of Materials, 2012 - ACS Publications
The field of polymer therapeutics has evolved over the past decade and has resulted in the
development of polymer–drug conjugates with a wide variety of architectures and chemical …

Biomimetic materials for tissue engineering

H Shin, S Jo, AG Mikos - Biomaterials, 2003 - Elsevier
The development of biomaterials for tissue engineering applications has recently focused on
the design of biomimetic materials that are capable of eliciting specific cellular responses …

Nanoparticle-assisted combination therapies for effective cancer treatment

CMJ Hu, S Aryal, L Zhang - Therapeutic delivery, 2010 - Taylor & Francis
Combination chemotherapy and nanoparticle drug delivery are two areas that have shown
significant promise in cancer treatment. Combined therapy of two or more drugs promotes …

Advances in biomaterials, drug delivery, and bionanotechnology

R Langer, NA Peppas - AIChE Journal, 2003 - Wiley Online Library
Biomaterials are widely used in numerous medical applications. Chemical engineering has
played a central role in this research and development. Polymers as biomaterials, materials …

Stimuli-responsive prodrug-based cancer nanomedicine

A **e, S Hanif, J Ouyang, Z Tang, N Kong, NY Kim… - …, 2020 - thelancet.com
The rapid development of nanotechnology results in the emergence of nanomedicines, but
the effective delivery of drugs to tumor sites remains a great challenge. Prodrug-based …

HPMA copolymers: origins, early developments, present, and future

J Kopeček, P Kopečková - Advanced drug delivery reviews, 2010 - Elsevier
The overview covers the discovery of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers, initial studies on their synthesis, evaluation of biological properties, and …

Effective drug delivery by PEGylated drug conjugates

RB Greenwald, YH Choe, J McGuire… - Advanced drug delivery …, 2003 - Elsevier
The current review presents an update of drug delivery using poly (ethylene glycol)(PEG),
that focuses on recent developments in both protein and organic drugs. Certainly the past 10 …

Intelligent polymeric micelles from functional poly (ethylene glycol)-poly (amino acid) block copolymers

Y Bae, K Kataoka - Advanced drug delivery reviews, 2009 - Elsevier
This review describes our recent efforts on the design and preparation of intelligent
polymeric micelles from functional poly (ethylene glycol)-poly (amino acid)(PEG-PAA) block …