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The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment
Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …
energy production. Several studies have found a relationship between mitochondrial …
The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications
In some patients with major depressive disorder (MDD), individual illness characteristics
appear consistent with those of a neuroprogressive illness. Features of neuroprogression …
appear consistent with those of a neuroprogressive illness. Features of neuroprogression …
Dysregulation of mitochondrial dynamics, mitophagy and apoptosis in major depressive disorder: Does inflammation play a role?
Recent studies have suggested that mitochondrial dysfunction and dysregulated
neuroinflammatory pathways are involved in the pathophysiology of major depressive …
neuroinflammatory pathways are involved in the pathophysiology of major depressive …
The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression
Although multiple hypotheses had been proposed to clarify the causes of depression, the
accurate pathogenesis and effective treatment of depression still need to be solved …
accurate pathogenesis and effective treatment of depression still need to be solved …
Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression
Mitochondrial dysfunction might have a central role in the pathophysiology of depression.
Phenotypically, depression is characterized by lack of energy, concentration problems and …
Phenotypically, depression is characterized by lack of energy, concentration problems and …
The energy metabolism dysfunction in psychiatric disorders postmortem brains: focus on proteomic evidence
Psychiatric disorders represent a great medical and social challenge and people suffering
from these conditions face many impairments regarding personal and professional life. In …
from these conditions face many impairments regarding personal and professional life. In …
A mitochondrial bioenergetic basis of depression
Major depressive disorder (MDD) is an important public health problem affecting 350 million
people worldwide. After decades of study, the pathophysiology of MDD remains elusive …
people worldwide. After decades of study, the pathophysiology of MDD remains elusive …
Mitochondrial health index correlates with plasma circulating cell-free mitochondrial DNA in bipolar disorder
Although mitochondrial dysfunction is known to play an essential role in the pathophysiology
of bipolar disorder (BD), there is a glaring gap in our understanding of how mitochondrial …
of bipolar disorder (BD), there is a glaring gap in our understanding of how mitochondrial …
Mitochondria in depression: The dysfunction of mitochondrial energy metabolism and quality control systems
M Jiang, L Wang, H Sheng - CNS Neuroscience & Therapeutics, 2024 - Wiley Online Library
Background Depression is the most disabling neuropsychiatric disorder, causing difficulties
in daily life activities and social interactions. The exact mechanisms of depression remain …
in daily life activities and social interactions. The exact mechanisms of depression remain …
Mitochondria and the economy of stress (mal) adaptation
Stress-associated diseases, like depression have a life time prevalence of up to 20%, and
approximately 18.4 million people in Europe suffer from depression. Despite decades of …
approximately 18.4 million people in Europe suffer from depression. Despite decades of …