Cellular senescence is a ubiquitous process with roles in tissue remodelling, including
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …

Seasonal influenza viruses cause recurring global epidemics by continually evolving to
escape host immunity. The viral constraints and host immune responses that limit and drive …

Abstract Purpose of Review Coronavirus disease of 2019 (COVID-19) is a cause of
significant morbidity and mortality worldwide. While cardiac injury has been demonstrated in …

B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

Genetic and epigenetic intra-tumoral heterogeneity cooperate to shape the evolutionary
course of cancer. Chronic lymphocytic leukaemia (CLL) is a highly informative model for …

Innate and adaptive immune responses decline with age, leading to greater susceptibility to
infectious diseases and reduced responses to vaccines. Diseases are more severe in old …

The adaptive immune system recognizes antigens via an immense array of antigen-binding
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …

Understanding humoral immune responses to SARS-CoV-2 infection will play a critical role
in the development of vaccines and antibody-based interventions. We report systemic and …

Influenza is a global public health problem. Current seasonal influenza vaccines have highly
variable efficacy, and thus attempts to develop broadly protective universal influenza …

Influenza is a leading cause of death in the elderly, and the vaccine protects only a fraction
of this population. A key aspect of antibody-mediated anti-influenza virus immunity is …