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State-of-the-art strategies for targeting the DNA damage response in cancer
Genomic instability is a key hallmark of cancer that arises owing to defects in the DNA
damage response (DDR) and/or increased replication stress. These alterations promote the …
damage response (DDR) and/or increased replication stress. These alterations promote the …
Genome-wide association studies of cancer: current insights and future perspectives
A Sud, B Kinnersley, RS Houlston - Nature Reviews Cancer, 2017 - nature.com
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
[HTML][HTML] Pathogenic germline variants in 10,389 adult cancers
We conducted the largest investigation of predisposition variants in cancer to date,
discovering 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 …
discovering 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 …
Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets
BA Nacev, F Sanchez-Vega, SA Smith… - Nature …, 2022 - nature.com
The genetic, biologic, and clinical heterogeneity of sarcomas poses a challenge for the
identification of therapeutic targets, clinical research, and advancing patient care. Because …
identification of therapeutic targets, clinical research, and advancing patient care. Because …
Germline and somatic genetics of osteosarcoma—connecting aetiology, biology and therapy
DM Gianferante, L Mirabello, SA Savage - Nature Reviews …, 2017 - nature.com
Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …
cancer of bone, have changed very little over the past 30 years. The peak incidence of …
Therapy-related myeloid neoplasms: when genetics and environment collide
ME McNerney, LA Godley, MM Le Beau - Nature Reviews Cancer, 2017 - nature.com
Therapy-related myeloid neoplasms (t-MN) arise as a late effect of chemotherapy and/or
radiation administered for a primary condition, typically a malignant disease, solid organ …
radiation administered for a primary condition, typically a malignant disease, solid organ …
Frequency of pathogenic germline variants in cancer-susceptibility genes in patients with osteosarcoma
L Mirabello, B Zhu, R Koster, E Karlins, M Dean… - JAMA …, 2020 - jamanetwork.com
Importance Osteosarcoma, the most common malignant bone tumor in children and
adolescents, occurs in a high number of cancer predisposition syndromes that are defined …
adolescents, occurs in a high number of cancer predisposition syndromes that are defined …
Childhood cancer predisposition syndromes—a concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric …
T Ripperger, SS Bielack, A Borkhardt… - American journal of …, 2017 - Wiley Online Library
Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes …
Although a large number of cancer predisposition genes and their associated syndromes …
UK guidelines for the management of soft tissue sarcomas
AJ Hayes, IF Nixon, DC Strauss, BM Seddon… - British Journal of …, 2024 - nature.com
Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues and can occur
almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location …
almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location …
Adult-onset cancer predisposition syndromes in children and adolescents—to test or not to test?
With the increasing use of comprehensive germline genetic testing of children and
adolescents with cancer, it has become evident that pathogenic variants (PV) in adult-onset …
adolescents with cancer, it has become evident that pathogenic variants (PV) in adult-onset …