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DNA alkylation damage by nitrosamines and relevant DNA repair pathways
J Fahrer, M Christmann - International journal of molecular sciences, 2023 - mdpi.com
Nitrosamines occur widespread in food, drinking water, cosmetics, as well as tobacco smoke
and can arise endogenously. More recently, nitrosamines have been detected as impurities …
and can arise endogenously. More recently, nitrosamines have been detected as impurities …
Epigenetic regulation of genomic stability by vitamin C
JP Brabson, T Leesang, S Mohammad… - Frontiers in genetics, 2021 - frontiersin.org
DNA methylation plays an important role in the maintenance of genomic stability. Ten-
eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG-dependent …
eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG-dependent …
Discovery of a potent and cell-active inhibitor of DNA 6mA demethylase ALKBH1
L ** diseases such as cancer and age-related disorders. DNA …
How human TET2 enzyme catalyzes the oxidation of unnatural cytosine modifications in double-stranded DNA
Methylation of cytosine bases is strongly linked to gene expression, imprinting, aging, and
carcinogenesis. The ten-eleven translocation (TET) family of enzymes, which are Fe (II)/2 …
carcinogenesis. The ten-eleven translocation (TET) family of enzymes, which are Fe (II)/2 …
Catalytic mechanism of human ten-eleven translocation-2 (tet2) enzyme: Effects of conformational changes, electric field, and mutations
Ten-eleven translocation (TET) family of enzymes are non-heme Fe (II)-and 2-oxoglutarate
(2OG)-dependent oxygenases that perform oxidation of the methyl group of the 5 …
(2OG)-dependent oxygenases that perform oxidation of the methyl group of the 5 …
Reversal of nucleobase methylation by dioxygenases
The repertoire of nucleobase methylation in DNA and RNA, introduced by chemical agents
or enzymes, is large. Most methylation can be reversed either directly by restoration of the …
or enzymes, is large. Most methylation can be reversed either directly by restoration of the …
The role of demethylase AlkB homologs in cancer
Q Li, Q Zhu - Frontiers in Oncology, 2023 - frontiersin.org
The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)-and α-ketoglutarate-
dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of …
dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of …